Biology:Delta-like 1
From HandWiki
 Generic protein structure example |
Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]
Function
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]
Interactions
Delta-like 1 has been shown to interact with NOTCH2[2][3][4]
References
- ↑ 1.0 1.1 "Entrez Gene: DLL1 delta-like 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514.
- ↑ "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. July 2001. doi:10.1074/jbc.M103473200. PMID 11346656.
- ↑ "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell 90 (2): 281–91. July 1997. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302.
- ↑ "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. September 2000. doi:10.1128/mcb.20.18.6913-6922.2000. PMID 10958687.
Further reading
- "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. 2002. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
- "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. 1999. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718.
- "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. 1999. doi:10.1006/dbio.1998.9092. PMID 9882480.
- "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. 1999. doi:10.1016/S0002-9440(10)65325-4. PMID 10079256.
- "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. 1999. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134.
- "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. 1999. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135.
- "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood 95 (5): 1616–25. 2000. doi:10.1182/blood.V95.5.1616.005k31_1616_1625. PMID 10688816.
- "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. 2000. doi:10.1128/MCB.20.18.6913-6922.2000. PMID 10958687.
- "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. 2000. doi:10.1006/bbrc.2000.3469. PMID 11006133.
- "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. 2001. doi:10.1084/jem.194.7.991. PMID 11581320.
- "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. 2002. doi:10.1093/emboj/21.3.294. PMID 11823422.
- "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. 2002. doi:10.1074/jbc.M204445200. PMID 12036964.
- "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. 2002. doi:10.1074/jbc.M203727200. PMID 12050162.
- "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. 2002. doi:10.1172/JCI16167. PMID 12393852.
- "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. 2003. doi:10.1073/pnas.252624099. PMID 12482954.
- "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. 2003. doi:10.3892/ijo.22.5.1073. PMID 12684674.
- "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. 2003. doi:10.1073/pnas.1230693100. PMID 12794186.
- "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. 2003. doi:10.1074/jbc.M302659200. PMID 12826675.
 |
