Biology:IFI30
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.[1][2][3]
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.[3]
References
- ↑ "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem 263 (24): 12036–43. Sep 1988. doi:10.1016/S0021-9258(18)37889-X. PMID 3136170.
- ↑ "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A 97 (2): 745–50. Mar 2000. doi:10.1073/pnas.97.2.745. PMID 10639150. Bibcode: 2000PNAS...97..745A.
- ↑ 3.0 3.1 "Entrez Gene: IFI30 interferon, gamma-inducible protein 30". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10437.
Further reading
- Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet 20 (1): 1. PMID 16170.
- Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association 52 (1): 9. PMID 1069150.
- "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. 2000. doi:10.1074/jbc.M003459200. PMID 10852914.
- "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics 53 (4): 342–6. 2001. doi:10.1007/s002510100323. PMID 11491538.
- Haque MA; Li P; Jackson SK et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMID 12021307.
- "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. 2002. doi:10.1073/pnas.182430499. PMID 12198183. Bibcode: 2002PNAS...9912298P.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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