Biology:H1299
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H1299, also known as NCI-H1299[1][2] or CRL-5803,[3] is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.[4] As with other immortalized cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which in part accounts for their proliferative propensity.[5] These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP).[4]
References
- ↑ "NCI-Navy Medical Oncology Branch cell line supplement". J. Cell. Biochem. Suppl. 24: 1–291. 1996. PMID 8965489.
- ↑ "ATCC Advanced Catalog Search". http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CRL-5803&Template=cellBiology.
- ↑ "CRL-5803/NCI-H1299 cell line". LGC Promochem: Cell Biology Collection. American Type Culture Collection. http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CRL-5803&Template=cellBiology.
- ↑ 4.0 4.1 "Neuromedin B is present in lung cancer cell lines". Cancer Res. 52 (9 Suppl): 2732s–2736s. May 1992. PMID 1563005. http://cancerres.aacrjournals.org/cgi/content/abstract/52/9_Supplement/2732s.
- ↑ "p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily". J. Biol. Chem. 271 (25): 14649–52. June 1996. doi:10.1074/jbc.271.25.14649. PMID 8663350.
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