Biology:EMSY
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EMSY is a protein that in humans is encoded by the EMSY gene.[1]
Clinical significance
EMSY has been shown to associate with atopy and susceptibility to poly-sensitisation.[2]
Interactions
EMSY has been shown to interact with ZMYND11,[3] BRCA2[3] and CBX1.[3]
References
- ↑ "Entrez Gene: C11orf30 chromosome 11 open reading frame 30". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56946.
- ↑ Amaral, A. F. S.; Minelli, C.; Guerra, S.; Wjst, M.; Probst-Hensch, N.; Pin, I.; Svanes, C.; Janson, C. et al. (March 2015). "The locus C11orf30 increases susceptibility to poly-sensitization". Allergy 70 (3): 328–333. doi:10.1111/all.12557. PMID 25546184.
- ↑ 3.0 3.1 3.2 "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell 115 (5): 523–35. Nov 2003. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.
External links
- Human C11orf30 genome location and C11orf30 gene details page in the UCSC Genome Browser.
Further reading
- "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell 115 (5): 523–35. 2003. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.
- "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 3059–64. 2004. doi:10.1073/pnas.0308746101. PMID 14981236.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935.
- "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69". EMBO Rep. 6 (7): 675–80. 2005. doi:10.1038/sj.embor.7400415. PMID 15947784.
- "Crystal structure of the ENT domain of human EMSY". J. Mol. Biol. 350 (5): 964–73. 2005. doi:10.1016/j.jmb.2005.05.047. PMID 15978617.
- "Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs". BMC Cancer 5: 81. 2005. doi:10.1186/1471-2407-5-81. PMID 16029503.
- "Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY". J. Natl. Cancer Inst. 97 (17): 1302–6. 2005. doi:10.1093/jnci/dji254. PMID 16145051.
- "Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas". Gynecol. Oncol. 100 (2): 264–70. 2006. doi:10.1016/j.ygyno.2005.08.026. PMID 16236351.
- "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding". Structure 14 (4): 703–12. 2006. doi:10.1016/j.str.2006.01.007. PMID 16615912.
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