Biology:CBX1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.

Function

The protein is localized at heterochromatin sites, where it mediates gene silencing.

Interactions

CBX1 has been shown to interact with:

• C11orf30,
• CBX3 and
• CBX5, and
• SUV39H1.

See also

• Heterochromatin protein 1

Further reading

• "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood 91 (4): 1216–24. Feb 1998. doi:10.1182/blood.V91.4.1216. PMID 9454751. 
• "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". The EMBO Journal 18 (7): 1923–38. Apr 1999. doi:10.1093/emboj/18.7.1923. PMID 10202156. 
• "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma 108 (4): 220–34. Aug 1999. doi:10.1007/s004120050372. PMID 10460410. 
• "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins". Molecular Cell 4 (4): 529–40. Oct 1999. doi:10.1016/S1097-2765(00)80204-X. PMID 10549285. 
• "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". The EMBO Journal 18 (22): 6385–95. Nov 1999. doi:10.1093/emboj/18.22.6385. PMID 10562550. 
• "The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer". The EMBO Journal 19 (7): 1587–97. Apr 2000. doi:10.1093/emboj/19.7.1587. PMID 10747027. 
• "Heterochromatin protein 1 binds to nucleosomes and DNA in vitro". The Journal of Biological Chemistry 275 (36): 28332–8. Sep 2000. doi:10.1074/jbc.M003493200. PMID 10882726. 
• "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature 410 (6824): 116–20. Mar 2001. doi:10.1038/35065132. PMID 11242053. 
• "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature 410 (6824): 120–4. Mar 2001. doi:10.1038/35065138. PMID 11242054. 
• "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Molecular Cell 7 (4): 729–39. Apr 2001. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697. 
• "Directed proteomic analysis of the human nucleolus". Current Biology 12 (1): 1–11. Jan 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". The Journal of Pathology 196 (2): 135–44. Feb 2002. doi:10.1002/path.1016. PMID 11793364. 
• "Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9". Nature 416 (6876): 103–7. Mar 2002. doi:10.1038/nature722. PMID 11882902. Bibcode: 2002Natur.416..103N. 
• "Isoform-specific interaction of HP1 with human TAFII130". Proceedings of the National Academy of Sciences of the United States of America 99 (9): 5919–24. Apr 2002. doi:10.1073/pnas.092025499. PMID 11959914. Bibcode: 2002PNAS...99.5919V. 
• "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochemical and Biophysical Research Communications 293 (4): 1217–22. May 2002. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505. 
• "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma 111 (2): 80–95. Jul 2002. doi:10.1007/s00412-002-0192-6. PMID 12111331. 
• "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1". Journal of Cell Science 115 (Pt 23): 4433–45. Dec 2002. doi:10.1242/jcs.00123. PMID 12414990. 
• "Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells". Science 299 (5607): 719–21. Jan 2003. doi:10.1126/science.1078694. PMID 12560554. Bibcode: 2003Sci...299..719F. 

External links

• CBX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CBX1 genome location and CBX1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.