Biology:ASF1A
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Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.[1][2][3]
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.[3]
Interactions
ASF1A has been shown to interact with TLK1,[4][5] TLK2,[4] CHAF1B[6] and CHAF1A.[6]
References
- ↑ "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research 10 (5): 703–13. May 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. Oct 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ 3.0 3.1 "Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25842.
- ↑ 4.0 4.1 "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology 11 (13): 1068–73. Jul 2001. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ 6.0 6.1 "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports 3 (4): 329–34. Apr 2002. doi:10.1093/embo-reports/kvf068. PMID 11897662.
Further reading
- "A human homologue of yeast anti-silencing factor has histone chaperone activity". Genes to Cells 5 (3): 221–33. Mar 2000. doi:10.1046/j.1365-2443.2000.00319.x. PMID 10759893.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology 11 (13): 1068–73. Jul 2001. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
- "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports 3 (4): 329–34. Apr 2002. doi:10.1093/embo-reports/kvf068. PMID 11897662.
- "Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID". Proceedings of the National Academy of Sciences of the United States of America 99 (14): 9334–9. Jul 2002. doi:10.1073/pnas.142627899. PMID 12093919. Bibcode: 2002PNAS...99.9334C.
- "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis". The Journal of Biological Chemistry 278 (37): 35660–7. Sep 2003. doi:10.1074/jbc.M303549200. PMID 12842904.
- "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis". Cell 116 (1): 51–61. Jan 2004. doi:10.1016/S0092-8674(03)01064-X. PMID 14718166.
- "1H, 13C and 15N resonance assignments of the conserved core of hAsf1 A". Journal of Biomolecular NMR 29 (3): 413–4. Jul 2004. doi:10.1023/B:JNMR.0000032497.24661.44. PMID 15213445.
- "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Developmental Cell 8 (1): 19–30. Jan 2005. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.
- "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell 17 (2): 301–11. Jan 2005. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
- "Structural basis for the interaction of Asf1 with histone H3 and its functional implications". Proceedings of the National Academy of Sciences of the United States of America 102 (17): 5975–80. Apr 2005. doi:10.1073/pnas.0500149102. PMID 15840725. Bibcode: 2005PNAS..102.5975M.
- "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly". Nature Structural & Molecular Biology 13 (10): 921–9. Oct 2006. doi:10.1038/nsmb1147. PMID 16980972.
- "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular Biology 7: 37. 2006. doi:10.1186/1471-2199-7-37. PMID 17054786.
- "Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights". Structure 15 (2): 191–9. Feb 2007. doi:10.1016/j.str.2007.01.002. PMID 17292837.
- "Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4". Nature 446 (7133): 338–41. Mar 2007. doi:10.1038/nature05613. PMID 17293877. Bibcode: 2007Natur.446..338N.
External links
- Human ASF1A genome location and ASF1A gene details page in the UCSC Genome Browser.
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