Biology:CHAF1A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.

Function

Chromatin assembly factor I (CAF-1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM]

Interactions

CHAF1A has been shown to interact with:

• ASF1A,
• ASF1B,
• BLM,
• CBX5, and
• MBD1.

Further reading

• "CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair". J. Cell Sci. 113 (15): 2647–58. 2000. doi:10.1242/jcs.113.15.2647. PMID 10893180. 
• "Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4". Cell 87 (1): 95–104. 1996. doi:10.1016/S0092-8674(00)81326-4. PMID 8858152. 
• "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle". J. Biol. Chem. 273 (24): 15279–86. 1998. doi:10.1074/jbc.273.24.15279. PMID 9614144. 
• "Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin". Cell 96 (4): 575–85. 1999. doi:10.1016/S0092-8674(00)80661-3. PMID 10052459. 
• "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins". Mol. Cell 4 (4): 529–40. 1999. doi:10.1016/S1097-2765(00)80204-X. PMID 10549285. 
• "A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage". Mol. Cell. Biol. 20 (4): 1206–18. 2000. doi:10.1128/MCB.20.4.1206-1218.2000. PMID 10648606. 
• "Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential". Mol. Cell. Biol. 20 (17): 6449–65. 2000. doi:10.1128/MCB.20.17.6449-6465.2000. PMID 10938122. 
• "Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene". Gene 264 (2): 187–96. 2001. doi:10.1016/S0378-1119(01)00335-3. PMID 11250073. 
• "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. 3 (4): 329–34. 2002. doi:10.1093/embo-reports/kvf068. PMID 11897662. 
• "The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 23 (9): 3226–36. 2003. doi:10.1128/MCB.23.9.3226-3236.2003. PMID 12697822. 
• "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. Cell Sci. 116 (Pt 14): 2929–36. 2004. doi:10.1242/jcs.00480. PMID 12771185. 
• "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. 2003. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248. 
• "Gene expression profiling predicts clinical outcome of prostate cancer". J. Clin. Invest. 113 (6): 913–23. 2004. doi:10.1172/JCI20032. PMID 15067324. 
• "Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 24 (11): 4710–9. 2004. doi:10.1128/MCB.24.11.4710-4719.2004. PMID 15143166. 
• "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly". Mol. Cell 15 (4): 595–605. 2004. doi:10.1016/j.molcel.2004.06.043. PMID 15327775. 

External links

• CHAF1A human gene location in the UCSC Genome Browser.
• CHAF1A human gene details in the UCSC Genome Browser.