Biology:WDR57
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WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.[1]
Function
This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.[1]
Interactions
WDR57 has been shown to interact with PRPF8[2][3] and EFTUD2.[2][3]
References
- ↑ 1.0 1.1 "Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9410.
- ↑ 2.0 2.1 "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ 3.0 3.1 "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology 18 (11): 6756–66. Nov 1998. doi:10.1128/mcb.18.11.6756. PMID 9774689.
Further reading
- "Roles of the U5 snRNP in spliceosome dynamics and catalysis". Biochemical Society Transactions 32 (Pt 6): 928–31. Dec 2004. doi:10.1042/BST0320928. PMID 15506927.
- "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics 20 (1): 46–50. Sep 1998. doi:10.1038/1700. PMID 9731529.
- "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology 18 (11): 6756–66. Nov 1998. doi:10.1128/mcb.18.11.6756. PMID 9774689.
- "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". Journal of Molecular Biology 298 (4): 567–75. May 2000. doi:10.1006/jmbi.2000.3685. PMID 10788320.
- "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. Apr 2002. doi:10.1017/S1355838202021088. PMID 11991638.
- "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nature Genetics 38 (2): 197–202. Feb 2006. doi:10.1038/ng1727. PMID 16429158. https://lirias.kuleuven.be/handle/123456789/8070.
- "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP". RNA 12 (7): 1418–30. Jul 2006. doi:10.1261/rna.55406. PMID 16723661.
- "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology 8 (11): 1277–83. Nov 2006. doi:10.1038/ncb1490. PMID 17041588.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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