Chemistry:CP-944629
From HandWiki
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| Preferred IUPAC name
3-tert-Butyl-6-[4-(2,4,5-trifluorophenyl)-1,3-oxazol-5-yl][1,2,4]triazolo[4,3-a]pyridine | |
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CompTox Dashboard (EPA)
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| Properties | |
| C19H15F3N4O | |
| Molar mass | 372.351 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
CP-944629, also known as 5-(3-tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole (IUPAC name),[1] is a small molecule that is predicted to block DNA transcription by inhibiting DNA topoisomerase.[2][3]
CP-944629 is thought to have anti-tumor activities.[3] CP-944629 is assumed to be a MAPK14 (mitogen-activated protein kinase 14 (human)) inhibitor[1] and a p38alpha inhibitor.[4]
References
- ↑ 1.0 1.1 PubChem. "1,2,4-Triazolo[4,3-Apyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-"] (in en). U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/9999342.
- ↑ "Gene Set - CP-944629-7497". New York City, U.S.: Icahn School of Medicine at Mount Sinai. http://amp.pharm.mssm.edu/Harmonizome/gene_set/CP-944629-7497/CMAP+Signatures+of+Differentially+Expressed+Genes+for+Small+Molecules.
- ↑ 3.0 3.1 Chung, Feng-Hsiang; Jin, Zhen-Hua; Hsu, Tzu-Ting; Hsu, Chueh-Lin; Liu, Hsueh-Chuan; Lee, Hoong-Chien (2015-10-16). "Gene-Set Local Hierarchical Clustering (GSLHC)—A Gene Set-Based Approach for Characterizing Bioactive Compounds in Terms of Biological Functional Groups". PLOS ONE 10 (10): e0139889. doi:10.1371/journal.pone.0139889. ISSN 1932-6203. PMID 26473729. Bibcode: 2015PLoSO..1039889C.
- ↑ "CP-944629 | CAS#668990-94-1 | p38α Inhibitor | MedKoo". https://www.medkoo.com/products/14674.
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