Biology:L2 holin family

Short description: Class of transmembrane transport proteins

The Putative Acholeplasma Phage L2 Holin (L2 Holin) Family (TC# 1.E.59) consists of a putative holin (TC# 1.E.59.1.1; 81 amino acyl residues (aas) and 2 transmembrane segments (TMSs)) and a homologous uncharacterized protein (TC# 1.E.59.1.2; 75 aas and 2 TMSs). These proteins are of particular interest because they may show a link between prokaryotic holins and eukaryotic virus viroporins. While functionally uncharacterized, this putative holin (TC# 1.E.59.1.1) comes up in BLAST searches when members of viroporin families TC# 1.A.95 and TC# 1.A.100 are used as query sequences.

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Nieva, José Luis; Madan, Vanesa; Carrasco, Luis. "Viroporins: structure and biological functions". Nature Reviews Microbiology 10 (8): 563–574. doi:10.1038/nrmicro2820.
• Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology 197(1): 7–17. doi:10.1128/JB.02046-14. ISSN 0021-9193. PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology 54: 799–825. doi:10.1146/annurev.micro.54.1.799. ISSN 0066-4227. PMID 11018145.

References

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