Biology:Vac7
From HandWiki
| Vacuolar segregation protein 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | VAC7 | ||||||
| Entrez | 855673 | ||||||
| RefSeq (mRNA) | NM_001182893 | ||||||
| RefSeq (Prot) | NP_014344 | ||||||
| UniProt | P53950 | ||||||
| Other data | |||||||
| Chromosome | XIV: 0.53 - 0.53 Mb | ||||||
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Vacuolar segregation protein 7 is a protein that in yeast is encoded by the VAC7 gene. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7.
Function
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). VAC7 activates FAB1 kinase for example during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. VAC7 is directly involved in vacuolar membrane scission and is required for normal vacuole acidification, inheritance and morphology.[1][2][3][4][5]
References
- ↑ UniProt P53950
- ↑ "Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology". Mol. Cell. Biol. 17 (12): 6847–58. December 1997. doi:10.1128/MCB.17.12.6847. PMID 9372916.
- ↑ "Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member". Mol. Biol. Cell 13 (4): 1238–51. April 2002. doi:10.1091/mbc.01-10-0498. PMID 11950935.
- ↑ "The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover". J. Cell Biol. 172 (5): 693–704. February 2006. doi:10.1083/jcb.200512105. PMID 16492811.
- ↑ "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse". EMBO J. 27 (24): 3221–34. December 2008. doi:10.1038/emboj.2008.248. PMID 19037259. PMC 2600653. https://dash.harvard.edu/bitstream/handle/1/5311764/2600653.pdf?sequence=1.
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