Biology:WIPI protein family

From HandWiki

The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins.[1] WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy,[1] and contain a conserved motif for interaction with phospholipids.[2]

Members of this family include:

Protein Gene Aliases Yeast
WIPI-1 WIPI1 WIPI49, FLJ10055 Atg18
WIPI-2 WIPI2 Svp1a, DKFZP434J154 WIPI49-like protein 2 Atg21
WIPI-3 WDR45L 628 protein, WIPI49-like protein
WIPI-4 WDR45 JM5 protein, WDRX1

References

  1. 1.0 1.1 "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene 23 (58): 9314–25. December 2004. doi:10.1038/sj.onc.1208331. PMID 15602573. 
  2. "Entrez Gene: WIPI2 WD repeat domain, phosphoinositide interacting 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26100.