Chemistry:7,8,3'-Trihydroxyflavone
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Short description: Chemical compound
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| Other names | 7,8,3'-THF |
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| Formula | C15H10O5 |
| Molar mass | 270.240 g·mol−1 |
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7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from tropoflavin (7,8-DHF).[1][2] Relative to tropoflavin, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist.[1][2] 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than tropoflavin in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity.[1] 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to tropoflavin.[2][3]
See also
References
- ↑ 1.0 1.1 1.2 "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry 53 (23): 8274–86. December 2010. doi:10.1021/jm101206p. PMID 21073191.
- ↑ 2.0 2.1 2.2 "7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo". Biochemical and Biophysical Research Communications 422 (3): 387–92. June 2012. doi:10.1016/j.bbrc.2012.04.154. PMID 22575512.
- ↑ "Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists". The Journal of Neuroscience 33 (32): 13042–52. August 2013. doi:10.1523/JNEUROSCI.0854-13.2013. PMID 23926258.
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