Chemistry:Lipo-oxytocin-1

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Short description: Chemical compound
Lipo-oxytocin-1
Lipo-oxytocin-1.svg
Chemical and physical data
FormulaC75H126N12O14S2
Molar mass1484.02 g·mol−1

Lipo-oxytocin-1 (LOT-1) is a synthetic peptide and derivative of oxytocin that acts as an agonist of the oxytocin receptor.[1] The lipidation strategy was applied to oxytocin to create a new peptide with improved pharmacokinetics.[1] LOT-1 consists of oxytocin conjugated with two palmitoyl groups.[1] After adjusting for molecular weight (LOT-1 is ~1.5x the weight of oxytocin), oxytocin and LOT-1 are equipotent.[1] In addition, LOT-1 appears to have a significantly longer duration of effect relative to that of oxytocin.[1] It has yet to be determined whether LOT-1 possesses improved blood-brain-barrier permeability relative to oxytocin.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice". Brain Sci 5 (1): 3–13. 2015. doi:10.3390/brainsci5010003. PMID 25612002. 




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