Biology:MCF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The DBL proto-oncogene is a protein that in humans is encoded by the MCF2 gene.[1][2][3]
The commonly-used name DBL is derived from “diffuse B-cell lymphoma”, the cancer type where this gene was first identified as an oncogene,[4] while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.[5]
DBL is the founding member of a large family of guanine nucleotide exchange factors that share a common DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it. In particular, DBL activates the Rho family member Cdc42.[6]
Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM][3]
References
- ↑ "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene 3 (6): 709–15. December 1988. PMID 2577874.
- ↑ "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics 60 (2): 114–6. Jul 1992. doi:10.1159/000133316. PMID 1611909.
- ↑ 3.0 3.1 "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168.
- ↑ "Isolation of a new human oncogene from a diffuse B-cell lymphoma". Nature 316 (6025): 273–5. 1985-07-18. doi:10.1038/316273a0. PMID 3875039. Bibcode: 1985Natur.316..273E.
- ↑ "Localization of the mcf.2 transforming sequence to the X chromosome". The EMBO Journal 6 (5): 1301–7. May 1987. doi:10.1002/j.1460-2075.1987.tb02368.x. PMID 3038515.
- ↑ "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution 9 (6): 1471–1486. June 2017. doi:10.1093/gbe/evx100. PMID 28541439.
Further reading
- "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr". The New Biologist 3 (4): 372–9. April 1991. PMID 2065022.
- "Chromosomal localization of DBL oncogene sequences". Genomics 5 (3): 546–53. October 1989. doi:10.1016/0888-7543(89)90022-0. PMID 2613238. https://zenodo.org/record/1258565.
- "Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells". The EMBO Journal 7 (8): 2465–73. August 1988. doi:10.1002/j.1460-2075.1988.tb03093.x. PMID 3056717.
- "The predicted DBL oncogene product defines a distinct class of transforming proteins". Proceedings of the National Academy of Sciences of the United States of America 85 (7): 2061–5. April 1988. doi:10.1073/pnas.85.7.2061. PMID 3281159. Bibcode: 1988PNAS...85.2061E.
- "Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 8868–72. December 1986. doi:10.1073/pnas.83.23.8868. PMID 3491366. Bibcode: 1986PNAS...83.8868S.
- "Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product". The Journal of Biological Chemistry 269 (1): 62–5. January 1994. doi:10.1016/S0021-9258(17)42313-1. PMID 8276860.
- "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Letters 459 (2): 186–90. October 1999. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015.
- "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation". Biochemical and Biophysical Research Communications 268 (1): 141–7. February 2000. doi:10.1006/bbrc.2000.2106. PMID 10652228.
- "Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation". The Journal of Biological Chemistry 275 (34): 25993–6001. August 2000. doi:10.1074/jbc.M003780200. PMID 10854437.
- "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site". Gene 253 (1): 107–15. July 2000. doi:10.1016/S0378-1119(00)00212-2. PMID 10925207.
- "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research Communications 277 (3): 718–21. November 2000. doi:10.1006/bbrc.2000.3744. PMID 11062019.
- "Oligomerization of DH domain is essential for Dbl-induced transformation". Molecular and Cellular Biology 21 (2): 425–37. January 2001. doi:10.1128/MCB.21.2.425-437.2001. PMID 11134331.
- "Regulation of proto-Dbl by intracellular membrane targeting and protein stability". The Journal of Biological Chemistry 277 (22): 19745–53. May 2002. doi:10.1074/jbc.M111025200. PMID 11907027.
- "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry 277 (49): 47810–7. December 2002. doi:10.1074/jbc.M203816200. PMID 12376551.
- "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene". Biochemical and Biophysical Research Communications 299 (3): 455–8. December 2002. doi:10.1016/S0006-291X(02)02645-1. PMID 12445822.
- "Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene". Biochemical and Biophysical Research Communications 309 (4): 906–9. October 2003. doi:10.1016/j.bbrc.2003.08.088. PMID 13679059. http://www.lib.kobe-u.ac.jp/repository/90000273.pdf.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
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