Biology:SS18L1
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SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.[1]
Function
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18.[1]
Interactions
SS18L1 has been shown to interact with CREB-binding protein.[2] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26039.
- ↑ "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science 303 (5655): 197–202. January 2004. doi:10.1126/science.1089845. PMID 14716005. Bibcode: 2004Sci...303..197A.
- ↑ "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE 7 (3): e33834. 2012. doi:10.1371/journal.pone.0033834. PMID 22442726. Bibcode: 2012PLoSO...733834M.
Further reading
- "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. June 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- "Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene". Cytogenetics and Cell Genetics 92 (3–4): 310–9. 2001. doi:10.1159/000056920. PMID 11435705.
- "A novel fusion gene, SS18L1/SSX1, in synovial sarcoma". Genes, Chromosomes & Cancer 37 (2): 195–200. June 2003. doi:10.1002/gcc.10210. PMID 12696068.
- "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science 303 (5655): 197–202. January 2004. doi:10.1126/science.1089845. PMID 14716005. Bibcode: 2004Sci...303..197A.
- "A multifunctional domain of the calcium-responsive transactivator (CREST) that inhibits dendritic growth in cultured neurons". The Journal of Biological Chemistry 280 (26): 24738–43. July 2005. doi:10.1074/jbc.M504018200. PMID 15866867.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research 112 (3–4): 222–6. 2006. doi:10.1159/000089874. PMID 16484776.
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