Biology:NEK8
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.[1][2]
Function
Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.[1]
Clinical significance
Mutations in the NEK8 gene associated with nephronophthisis.[3][4]
References
- ↑ 1.0 1.1 "Entrez Gene: NIMA (never in mitosis gene a)- related kinase 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284086.
- ↑ "NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis". J. Am. Soc. Nephrol. 19 (3): 587–92. March 2008. doi:10.1681/ASN.2007040490. PMID 18199800.
- ↑ "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. June 2009. doi:10.1016/j.gde.2009.04.008. PMID 19477114.
- ↑ Zalli, D.; Bayliss, R.; Fry, A. M. (21 November 2011). "The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis". Human Molecular Genetics 21 (5): 1155–1171. doi:10.1093/hmg/ddr544. PMID 22106379.
Further reading
- "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.". Gene 328: 135–42. 2004. doi:10.1016/j.gene.2003.12.002. PMID 15019993.
- "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice.". Mol. Cell. Proteomics 4 (7): 1009–18. 2005. doi:10.1074/mcp.M500091-MCP200. PMID 15872312.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.". J. Biol. Chem. 277 (18): 16229–40. 2002. doi:10.1074/jbc.M108662200. PMID 11864968.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Nephronophthisis.". Eur. J. Hum. Genet. 17 (4): 406–16. 2009. doi:10.1038/ejhg.2008.238. PMID 19066617.
- "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics 7 (11): 1775–85. 2007. doi:10.1002/pmic.200601006. PMID 17474147.
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