Biology:IGHM

Short description: Gene in the species Homo sapiens

IGHM dimer, Human

Generic protein structure example

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.

It is associated with agammaglobulinemia-1.

Further reading

• "An estimate of the sequencing error frequency in the DNA sequence databases.". DNA Seq. 2 (6): 343–6. 1992. doi:10.3109/10425179209020815. PMID 1446073. 
• "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M.". Biochemistry 31 (50): 12643–7. 1993. doi:10.1021/bi00165a014. PMID 1472500. 
• "mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end.". Nucleic Acids Res. 19 (9): 2427–33. 1991. doi:10.1093/nar/19.9.2427. PMID 1904154. 
• "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.". J. Exp. Med. 172 (3): 973–6. 1990. doi:10.1084/jem.172.3.973. PMID 2117639. 
• "The complete nucleotide sequence of a human immunoglobulin genomic C mu gene.". Nucleic Acids Res. 17 (15): 6412. 1989. doi:10.1093/nar/17.15.6412. PMID 2505237. 
• "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9199–203. 1988. doi:10.1073/pnas.84.24.9199. PMID 3122216. 
• "Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin.". Science 182 (4109): 287–91. 1973. doi:10.1126/science.182.4109.287. PMID 4742735. Bibcode: 1973Sci...182..287P. 
• "[The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 354 (10–11): 1505–9. 1975. PMID 4803843. 
• "The primary structure of the constant part of mu-chain-disease protein BOT.". Eur. J. Biochem. 111 (1): 275–86. 1981. doi:10.1111/j.1432-1033.1980.tb06103.x. PMID 6777162. 
• "Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas.". Proc. Natl. Acad. Sci. U.S.A. 77 (10): 6027–31. 1981. doi:10.1073/pnas.77.10.6027. PMID 6777778. 
• "Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.". Nucleic Acids Res. 9 (18): 4509–24. 1982. doi:10.1093/nar/9.18.4509. PMID 6795593. 
• "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines.". J. Biol. Chem. 269 (45): 28347–53. 1994. doi:10.1016/S0021-9258(18)46934-7. PMID 7961773. 
• "Comparison of complete nucleotide sequence of the human IgM heavy chain constant region of polyreactive and monoreactive antibodies.". Mol. Immunol. 30 (1): 111–2. 1993. doi:10.1016/0161-5890(93)90434-D. PMID 8417370. 
• "The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity.". J. Immunol. 158 (4): 1681–91. 1997. doi:10.4049/jimmunol.158.4.1681. PMID 9029104. 
• "Glycosylated extracellular domains of membrane immunoglobulin M contribute to its association with mb-1/B29 gene products and the B cell receptor complex.". Immunol. Invest. 27 (1–2): 57–72. 1998. doi:10.3109/08820139809070890. PMID 9561918. 
• "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies.". Immunotechnology 4 (1): 37–47. 1998. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813. 
• "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression.". J. Immunol. 167 (7): 3846–57. 2001. doi:10.4049/jimmunol.167.7.3846. PMID 11564802. 
• "Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.". Clin. Cancer Res. 8 (2): 502–13. 2002. PMID 11839670. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.