Biology:CA11
 Generic protein structure example |
Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.[1][2]
Function
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[2]
Interactions
CA11 has been shown to interact with RIPK1.[3]
References
- ↑ "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3". Genomics 54 (3): 484–93. December 1998. doi:10.1006/geno.1998.5585. PMID 9878252.
- ↑ 2.0 2.1 "Entrez Gene: CA11 carbonic anhydrase XI". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=770.
- ↑ "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Curr. Biol. 18 (9): 641–9. May 2008. doi:10.1016/j.cub.2008.04.017. PMID 18450452.
External links
- Human CA11 genome location and CA11 gene details page in the UCSC Genome Browser.
Further reading
- "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3". Biochem. Biophys. Res. Commun. 253 (2): 364–7. 1998. doi:10.1006/bbrc.1998.9449. PMID 9878543.
- "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI". Biochim. Biophys. Acta 1431 (2): 518–24. 1999. doi:10.1016/S0167-4838(99)00067-9. PMID 10350627.
- "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain". Biochim. Biophys. Acta 1518 (3): 311–6. 2001. doi:10.1016/s0167-4781(01)00193-2. PMID 11311946.
- "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain". Neuroscience 112 (1): 93–9. 2002. doi:10.1016/S0306-4522(02)00066-0. PMID 12044474.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
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