Medicine:ST Genesia
The ST Genesia is a fully automated commercial analyzer system for performing thrombin generation assays (TGAs) and hence for coagulation testing.[1] It was developed by Diagnostica Stago and was introduced by the company in 2018.[2] Traditionally, TGAs has been conducted using partially automated methods like the calibrated automated thrombogram (CAT), which was introduced in 2003.[1][3][4] However, the CAT is performed in a 96-well plate and requires specialized technologists to be performed.[1] Consequently, it has seen low implementation in routine laboratories and has been more limited to research settings.[1][5] Lack of standardization with the CAT has also led to difficulties in study-to-study comparisons in research.[1][6] It has been said that the introduction of the ST Genesia system, which will allow TGAs to be performed more easily and also shows improved reproducibility compared to the CAT, should allow for more widespread adoption of TGAs in clinical laboratories.[1][7]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Can We Measure the Individual Prothrombotic or Prohemorrhagic Tendency by Global Coagulation Tests?". Hamostaseologie 40 (3): 364–378. August 2020. doi:10.1055/a-1153-5824. PMID 32726831.
- ↑ "Stago - Detail - ST Genesia launched!". https://www.stago.com/news/focus-on-haemostasis/detail/article/st-genesia-launched/.
- ↑ "A review of commercially available thrombin generation assays". Res Pract Thromb Haemost 2 (1): 42–48. January 2018. doi:10.1002/rth2.12048. PMID 30046705.
- ↑ "Thrombin generation assays are versatile tools in blood coagulation analysis: A review of technical features, and applications from research to laboratory routine". J Thromb Haemost 19 (12): 2907–2917. December 2021. doi:10.1111/jth.15529. PMID 34525255.
- ↑ "Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy". J Clin Endocrinol Metab 105 (7): e2369–e2377. July 2020. doi:10.1210/clinem/dgaa262. PMID 32413907.
- ↑ "Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk". Front Endocrinol (Lausanne) 12: 769187. 2021. doi:10.3389/fendo.2021.769187. PMID 34956081.
- ↑ "Recent Advances in Mainstream Hemostasis Diagnostics and Coagulation Testing". Semin Thromb Hemost 45 (3): 228–246. April 2019. doi:10.1055/s-0038-1676579. PMID 30912101.
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