Biology:IQGAP2
From HandWiki
 Generic protein structure example |
Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[1][2]
Function
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[2]
Interactions
IQGAP2 has been shown to interact with CDC42[1] and RAC1.[1]
References
- ↑ 1.0 1.1 1.2 "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. Sep 1996. doi:10.1128/mcb.16.9.4869. PMID 8756646.
- ↑ 2.0 2.1 "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10788.
Further reading
- "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. 1996. doi:10.1074/jbc.271.36.21732. PMID 8702968.
- "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine 15 (3): 122–37. 2001. doi:10.1006/cyto.2001.0891. PMID 11554782.
- "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. 2002. doi:10.1074/jbc.M203816200. PMID 12376551.
- "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood 101 (8): 3021–8. 2003. doi:10.1182/blood-2002-09-2807. PMID 12515716.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2003. doi:10.1038/nbt810. PMID 12665801.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
- "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. 2005. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
- "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. 2005. doi:10.1080/10425170400009012. PMID 15621655.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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