Biology:BNC1

Generic protein structure example

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.

BNC1 or Basonuclin 1 does not interact with PICK1. The suggestion that it does is based on the article that proved that PICK1 interacts with the non-voltage gated sodium channels BNC1 (brain Na⁺ channel 1). Both Basonuclin 1 and brain Na⁺ channel 1 have the same abbreviation BNC1, but they are not similar proteins and PICK1 interacts with the second protein, not the first one.

Further reading

• Tseng H (1998). "Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.". Front. Biosci. 3 (4): D985–8. doi:10.2741/A338. PMID 9727087. 
• "Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.". J. Cell Biol. 126 (2): 495–506. 1994. doi:10.1083/jcb.126.2.495. PMID 8034748. 
• "The human basonuclin gene.". Gene 188 (1): 1–7. 1997. doi:10.1016/S0378-1119(96)00659-2. PMID 9099851. 
• "An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.". J. Cell Biol. 137 (3): 657–69. 1997. doi:10.1083/jcb.137.3.657. PMID 9151672. 
• "Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7948–53. 1997. doi:10.1073/pnas.94.15.7948. PMID 9223293. Bibcode: 1997PNAS...94.7948I. 
• "Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.". Biol. Reprod. 59 (2): 388–94. 1998. doi:10.1095/biolreprod59.2.388. PMID 9687312. 
• "Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9628–32. 1999. doi:10.1073/pnas.96.17.9628. PMID 10449744. Bibcode: 1999PNAS...96.9628I. 
• "Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes.". J. Cell Sci. 112 Pt 18 (18): 3039–47. 2000. doi:10.1242/jcs.112.18.3039. PMID 10462520. 
• "A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation.". Gene 237 (1): 35–44. 1999. doi:10.1016/S0378-1119(99)00299-1. PMID 10524234. 
• "Alternative subcellular locations of keratinocyte basonuclin.". Exp. Dermatol. 9 (3): 178–84. 2000. doi:10.1034/j.1600-0625.2000.009003178.x. PMID 10839715. 
• "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197. 
• "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. 2005. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
• "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12423–8. 2006. doi:10.1073/pnas.0605086103. PMID 16891417. Bibcode: 2006PNAS..10312423V. 

External links

• Human BNC1 genome location and BNC1 gene details page in the UCSC Genome Browser.