Biology:AKAP11
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.[1][2][3]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.[3]
Interactions
AKAP11 has been shown to interact with:
- GSK3B,[4]
- PPP1CA,[4][5]
- PRKAR2A,[2][4][6]
- PRKAR2B.[7]
- VAPB.[8] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3. [9]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. December 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ 2.0 2.1 "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes". J. Biol. Chem. 271 (16): 9460–5. June 1996. doi:10.1074/jbc.271.16.9460. PMID 8621616. http://faculty.washington.edu/scottjdw/pdfs/lester_jbc_1996_p9460.pdf.
- ↑ 3.0 3.1 "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11215.
- ↑ 4.0 4.1 4.2 "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. October 2002. doi:10.1074/jbc.M206210200. PMID 12147701.
- ↑ "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. March 1999. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
- ↑ "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. April 2003. doi:10.1073/pnas.0330734100. PMID 12672969. Bibcode: 2003PNAS..100.4445A.
- ↑ "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. July 2000. doi:10.1006/dbio.2000.9725. PMID 10864471.
- ↑ "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell 162 (2): 425–40. 2015. doi:10.1016/j.cell.2015.06.043. PMID 26186194.
- ↑ "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.". PLOS ONE 7 (1): e30455. 2012. doi:10.1371/journal.pone.0030455. PMID 22276202. Bibcode: 2012PLoSO...730455M.
External links
- Human AKAP11 genome location and AKAP11 gene details page in the UCSC Genome Browser.
Further reading
- "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. 1997. PMID 9238861.
- "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. 2002. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2002. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. 1999. doi:10.1016/S0960-9822(99)80141-9. PMID 10209101.
- "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. 2000. doi:10.1006/dbio.2000.9725. PMID 10864471.
- "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation". J. Biol. Chem. 276 (15): 12128–34. 2001. doi:10.1074/jbc.M010398200. PMID 11152471.
- "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. 2002. doi:10.4049/jimmunol.168.4.1590. PMID 11823486.
- "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. 2002. doi:10.1074/jbc.M206210200. PMID 12147701.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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