Biology:SEPT4

Generic protein structure example

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• "Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins". Cell Motility and the Cytoskeleton 43 (1): 52–62. 1999. doi:10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5. PMID 10340703. 
• "A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif". Nature Cell Biology 2 (12): 915–21. December 2000. doi:10.1038/35046566. PMID 11146656. 
• "Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2". Gene 261 (2): 197–203. December 2000. doi:10.1016/S0378-1119(00)00527-8. PMID 11167005. 
• "Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion". Biochemical and Biophysical Research Communications 286 (3): 547–53. August 2001. doi:10.1006/bbrc.2001.5413. PMID 11511094. 
• "Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo". Cancer Gene Therapy 9 (6): 483–8. June 2002. doi:10.1038/sj.cgt.7700460. PMID 12032658. 
• "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". NeuroReport 14 (1): 31–7. January 2003. doi:10.1097/00001756-200301200-00006. PMID 12544826. 
• "Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies". The Journal of Biological Chemistry 278 (26): 24095–102. June 2003. doi:10.1074/jbc.M301352200. PMID 12695511. 
• "SEPT5_v2 is a parkin-binding protein". Brain Research. Molecular Brain Research 117 (2): 179–89. October 2003. doi:10.1016/S0169-328X(03)00318-8. PMID 14559152. 
• "The mitochondrial ARTS protein promotes apoptosis through targeting XIAP". The EMBO Journal 23 (7): 1627–35. April 2004. doi:10.1038/sj.emboj.7600155. PMID 15029247. 
• "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis 91 (5): 959–66. May 2004. doi:10.1160/TH03-09-0578. PMID 15116257. 
• "Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients". Oncogene 23 (32): 5468–75. July 2004. doi:10.1038/sj.onc.1207725. PMID 15122323. 
• "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal 382 (Pt 3): 783–91. September 2004. doi:10.1042/BJ20040372. PMID 15214843. 
• "Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation". The Journal of Biological Chemistry 280 (27): 25802–10. July 2005. doi:10.1074/jbc.M501955200. PMID 15837787. 
• "Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers". Pathology, Research and Practice 202 (2): 67–70. 2006. doi:10.1016/j.prp.2005.11.001. PMID 16376484. 
• "Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas". Acta Oncologica 45 (1): 101–2. 2006. doi:10.1080/02841860500374497. PMID 16464805. 
• "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4". Biochemistry 45 (46): 13918–31. November 2006. doi:10.1021/bi061549z. PMID 17105210.