Biology:NTN5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene.[1] Netrin-5 is included in the family of secreted laminin-related proteins.
Function
Netrin-5 functions are not fully clarified. However, it is believed to:
- Plays an important role in neurogenesis by controlling the development of dendrites and acting as a guide for axons.[2][3]
- Regulates cell migration in the brain during embryonic development.[4]
- Prevents motor neuron cell body migration out of the neural tube.[4]
Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.[5]
Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified.[6]
References
- ↑ "NTN5 netrin 5 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/126147.
- ↑ "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience 9: 146. 2015. doi:10.3389/fncel.2015.00146. PMID 25941474.
- ↑ "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience 14: 570974. 2020. doi:10.3389/fnins.2020.570974. PMID 33324143.
- ↑ 4.0 4.1 "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics 12 (5): 449–462. September 2011. doi:10.1093/bib/bbr042. PMID 21873635.
- ↑ "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics 53 (9): 1276–1282. September 2021. doi:10.1038/s41588-021-00921-z. PMID 34493870. https://research.vu.nl/en/publications/61f01aa9-6dc7-4213-be2a-d3fe622db488.
- ↑ "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids 2019: 3947123. 2019-02-24. doi:10.1155/2019/3947123. PMID 30923634.
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