Medicine:Combined rapid anterior pituitary evaluation panel
| Combined rapid anterior pituitary evaluation panel | |
|---|---|
| Medical diagnostics | |
| OPS-301 code | 1-797 |
A combined rapid anterior pituitary evaluation panel or triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's pituitary function. A triple bolus test is usually ordered and interpreted by endocrinologists.[citation needed]
In rare cases, it has been associated with pituitary apoplexy.[1]
Process
Three hormones[2] (usually synthetic analogues) are injected as a bolus into the patient's vein to stimulate the anterior pituitary gland:
The gland's response is assessed by measuring the rise in cortisol and growth hormone (GH) in response to the hypoglycaemia caused by insulin, rises in prolactin and thyroid-stimulating hormone (TSH) caused by TRH and rises in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) caused by GnRH. Blood glucose levels are also monitored to ensure appropriate levels of hypoglycemia are achieved.[citation needed]
History
The triple bolus test was introduced in 1973 by physicians from the London Royal Postgraduate Medical School and Queen Elizabeth Hospital, Birmingham.[3] It followed earlier reports combining insulin and vasopressin analogues in the diagnosis of hypopituitarism.[4]
See also
References
- ↑ "Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests". Acta Neurochir (Wien) 149 (6): 557–65; discussion 565. June 2007. doi:10.1007/s00701-007-1155-8. PMID 17468811.
- ↑ Melmed, Shlomo (2002). The pituitary. Wiley-Blackwell. pp. 714–. ISBN 978-0-632-04357-6. https://books.google.com/books?id=tVAnazIV1JwC&pg=PA714. Retrieved 15 July 2011.
- ↑ "Combined test for assessment of anterior pituitary function". Br Med J 4 (5888): 326–9. November 1973. doi:10.1136/bmj.4.5888.326. PMID 4202260.
- ↑ "Assessment of hypothalamic pituitary function in endocrine disease". J. Clin. Pathol. 19 (3): 284–92. May 1966. doi:10.1136/jcp.19.3.284. PMID 4287115.
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