Chemistry:Elamipretide
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Short description: Chemical compound
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| Other names | H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2; D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide |
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| Formula | C32H49N9O5 |
| Molar mass | 639.802 g·mol−1 |
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Elamipretide (also known as SS-31, , MTP-131 and Bendavia)[1][2] is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.[3]
Stealth Peptides, a privately held company, was founded in 2006 to develop intellectual property licensed from several universities including elamipretide; it subsequently changed its name to Stealth BioTherapeutics.[4][5]
As of November 2017 Stealth had obtained an orphan designation in the US for use in mitochondrial myopathy and had started a Phase III trial in that indication.[2] As of January 2020, trial expectations were not met.[6]
References
- ↑ "Recommended INN List 75". WHO Drug Information 30 (1): 111. 2016. https://www.who.int/medicines/publications/druginformation/innlists/RL75.pdf.
- ↑ 2.0 2.1 "Elamipretide" (in en). AdisInsight. http://adisinsight.springer.com/drugs/800032135.
- ↑ "New therapies for reducing post-myocardial left ventricular remodeling". Annals of Translational Medicine 3 (2): 20. February 2015. doi:10.3978/j.issn.2305-5839.2015.01.13. PMID 25738140.
- ↑ Valigra, Lori (April 9, 2012). "Stealth Peptides sees positive results from Bendavia". Boston Business Journal. http://www.bizjournals.com/boston/blog/mass-high-tech/2012/04/stealth-peptides-sees-positive-results-from.html.
- ↑ Dolgin, Elie (11 February 2016). "New drugs offer hope for mitochondrial disease". STAT. https://www.statnews.com/2016/02/11/mitochondrial-disease-therapies/.
- ↑ PhD, Alberto Molano (2020-01-10). "Elamipretide Failed to Meet Promise of Earlier Trial Results for..." (in en-US). https://mitochondrialdiseasenews.com/2020/01/10/elamipretide-failed-to-meet-promise-of-earlier-trial-results-for-primary-mitochondrial-myopathy-data-show/.
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