Chemistry:Velneperit
From HandWiki
Short description: Chemical compound
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| Formula | C17H24F3N3O3S |
| Molar mass | 407.45 g·mol−1 |
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Velneperit (S-2367) is a drug developed by Shionogi, which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y5. It has anorectic effects and was developed as a possible treatment for obesity, but was discontinued from further development after disappointing results in Phase II clinical trials. However it was still considered a successful proof of concept of the potential of Y5 receptor antagonists as possible anti-obesity agents in future.[1][2][3]
References
- ↑ "[A potent and selective neuropeptide Y Y5-receptor antagonist, S-2367, as an anti-obesity agent]" (in ja). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 136 (5): 270–4. November 2010. doi:10.1254/fpj.136.270. PMID 21079365.
- ↑ "Development of an Optimized Synthetic and Purification Process of S-2367 (Velneperit), a Novel Neuropeptide Y (NPY) Y5 Receptor Antagonist.". Organic Process Research & Development 19 (4): 531–6. April 2015. doi:10.1021/acs.oprd.5b00023.
- ↑ "New and emerging drug molecules against obesity". Journal of Cardiovascular Pharmacology and Therapeutics 19 (1): 65–76. January 2014. doi:10.1177/1074248413501017. PMID 24064009.
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