Biology:TRIM6
From HandWiki
 Generic protein structure example |
Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[1][2]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[2]
References
Further reading
- "Unique features of TRIM5alpha among closely related human TRIM family members.". Virology 360 (2): 419–33. 2007. doi:10.1016/j.virol.2006.10.035. PMID 17156811.
- "Antiretroviral potential of human tripartite motif-5 and related proteins.". Virology 353 (2): 396–409. 2006. doi:10.1016/j.virol.2006.05.035. PMID 16828831.
- "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.". J. Virol. 80 (13): 6198–206. 2006. doi:10.1128/JVI.00283-06. PMID 16775307.
- "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353–63. 2006. doi:10.1038/sj.emboj.7600994. PMID 16498413.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.". Genomics 69 (1): 143–9. 2001. doi:10.1006/geno.2000.6318. PMID 11013086.
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