Biology:RNF7
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
RNF7 has been shown to interact with CSNK2B.[4]
See also
References
- ↑ "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents". Mol Cell Biol 19 (4): 3145–55. April 1999. doi:10.1128/MCB.19.4.3145. PMID 10082581.
- ↑ "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell 3 (4): 535–41. May 1999. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407. http://cdr.lib.unc.edu/downloads/d791sr25b.
- ↑ 3.0 3.1 "Entrez Gene: RNF7 ring finger protein 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616.
- ↑ Ahn, B H; Kim T H; Bae Y S (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells (Korea (South)) 12 (2): 158–63. ISSN 1016-8478. PMID 11710515.
Further reading
- "Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha". Mol. Cell 3 (4): 527–33. 1999. doi:10.1016/S1097-2765(00)80481-5. PMID 10230406.
- "Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein". Free Radic. Biol. Med. 27 (1–2): 193–202. 1999. doi:10.1016/S0891-5849(99)00078-7. PMID 10443936.
- Sun Y (1999). "Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection". Carcinogenesis 20 (10): 1899–903. doi:10.1093/carcin/20.10.1899. PMID 10506102.
- "Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif". Biochem. Biophys. Res. Commun. 263 (3): 743–8. 1999. doi:10.1006/bbrc.1999.1460. PMID 10512750.
- "The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation". J. Biol. Chem. 275 (20): 15432–9. 2000. doi:10.1074/jbc.M907300199. PMID 10748083.
- "Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation". Oncogene 19 (24): 2855–66. 2000. doi:10.1038/sj.onc.1203635. PMID 10851089.
- "The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1". Mol. Cell. Biol. 20 (21): 8185–97. 2000. doi:10.1128/MCB.20.21.8185-8197.2000. PMID 11027288.
- "Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation". Mol. Carcinog. 30 (1): 37–46. 2001. doi:10.1002/1098-2744(200101)30:1<37::AID-MC1011>3.0.CO;2-7. PMID 11255262.
- "SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes". DNA Cell Biol. 20 (7): 425–34. 2001. doi:10.1089/104454901750361488. PMID 11506706. https://deepblue.lib.umich.edu/bitstream/2027.42/63441/1/104454901750361488.pdf.
- "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells 12 (2): 158–63. 2002. PMID 11710515.
- "Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins". J. Biol. Chem. 277 (18): 15758–65. 2002. doi:10.1074/jbc.M108565200. PMID 11861641.
- "Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein". Free Radic. Res. 36 (1): 73–8. 2002. doi:10.1080/10715760210164. PMID 11999705.
- "The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation". J. Biochem. Mol. Biol. 35 (6): 629–36. 2003. doi:10.5483/bmbrep.2002.35.6.629. PMID 12470599.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage". Biochem. Biophys. Res. Commun. 301 (3): 671–4. 2003. doi:10.1016/S0006-291X(03)00018-4. PMID 12565832.
- "Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1". J. Biol. Chem. 278 (31): 28462–9. 2003. doi:10.1074/jbc.M302584200. PMID 12748192.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- RNF7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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