Biology:DDT (gene)
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D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.[1][2][3]
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.[3]
See also
References
- ↑ "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun 243 (2): 538–44. Mar 1998. doi:10.1006/bbrc.1998.8123. PMID 9480844.
- ↑ "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 ( Pt 3) (3): 617–23. Nov 1998. doi:10.1042/bj3340617. PMID 9729470.
- ↑ 3.0 3.1 "Entrez Gene: DDT D-dopachrome tautomerase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1652.
Further reading
- "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. 1993. doi:10.1002/elps.11501301201. PMID 1286669.
- "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.". Biochem. Biophys. Res. Commun. 197 (2): 619–24. 1994. doi:10.1006/bbrc.1993.2524. PMID 8267597.
- "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.". Mamm. Genome 9 (9): 753–7. 1999. doi:10.1007/s003359900858. PMID 9716662.
- "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.". Biochemistry 38 (11): 3268–79. 1999. doi:10.1021/bi982184o. PMID 10079069.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.". J. Biol. Chem. 277 (28): 24976–82. 2002. doi:10.1074/jbc.M203220200. PMID 11997397.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor.". Exp. Dermatol. 12 (3): 278–82. 2004. doi:10.1034/j.1600-0625.2003.120307.x. PMID 12823441. http://lup.lub.lu.se/record/115723.
- "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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