Biology:SUZ12
From HandWiki
 Generic protein structure example |
Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.[1][2][3][4]
Function
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.[4]
SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.[5]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (4): 167–74, 199–210. August 1995. doi:10.1093/dnares/2.4.167. PMID 8590280.
- ↑ "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6348–53. May 2001. doi:10.1073/pnas.101132598. PMID 11371647. Bibcode: 2001PNAS...98.6348K.
- ↑ "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction 136 (6): 777–85. December 2008. doi:10.1530/REP-08-0045. PMID 18784248.
- ↑ 4.0 4.1 "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512.
- ↑ "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell 129 (7): 1311–23. June 2007. doi:10.1016/j.cell.2007.05.022. PMID 17604720.
Further reading
- "Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants". Development 128 (17): 3371–9. September 2001. doi:10.1242/dev.128.17.3371. PMID 11546753.
- "Use of chromatin immunoprecipitation to clone novel E2F target promoters". Molecular and Cellular Biology 21 (20): 6820–32. October 2001. doi:10.1128/MCB.21.20.6820-6832.2001. PMID 11564866.
- "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science 298 (5595): 1039–43. November 2002. doi:10.1126/science.1076997. PMID 12351676. Bibcode: 2002Sci...298.1039C.
- "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein". Genes & Development 16 (22): 2893–905. November 2002. doi:10.1101/gad.1035902. PMID 12435631.
- "Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations". Journal of Medical Genetics 40 (7): 520–5. July 2003. doi:10.1136/jmg.40.7.520. PMID 12843325.
- "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Molecular Cell 12 (2): 475–87. August 2003. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
- "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity". The American Journal of Surgical Pathology 28 (2): 224–32. February 2004. doi:10.1097/00000478-200402000-00010. PMID 15043312.
- "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Molecular Cell 15 (1): 57–67. July 2004. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
- "High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene". American Journal of Human Genetics 75 (3): 410–23. September 2004. doi:10.1086/423624. PMID 15257518.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity". The EMBO Journal 23 (20): 4061–71. October 2004. doi:10.1038/sj.emboj.7600402. PMID 15385962.
- "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3". Science 310 (5746): 306–10. October 2005. doi:10.1126/science.1118947. PMID 16224021. Bibcode: 2005Sci...310..306C.
- "Control of developmental regulators by Polycomb in human embryonic stem cells". Cell 125 (2): 301–13. April 2006. doi:10.1016/j.cell.2006.02.043. PMID 16630818.
- "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochemical and Biophysical Research Communications 345 (3): 1051–8. July 2006. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms". The American Journal of Surgical Pathology 31 (1): 65–70. January 2007. doi:10.1097/01.pas.0000213327.86992.d1. PMID 17197920.
External links
 |
