Biology:SUZ12

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.[1][2][3][4]

Function

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.[4]

SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.[5]

References

  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (4): 167–74, 199–210. August 1995. doi:10.1093/dnares/2.4.167. PMID 8590280. 
  2. "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6348–53. May 2001. doi:10.1073/pnas.101132598. PMID 11371647. Bibcode2001PNAS...98.6348K. 
  3. "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction 136 (6): 777–85. December 2008. doi:10.1530/REP-08-0045. PMID 18784248. 
  4. 4.0 4.1 "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512. 
  5. "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell 129 (7): 1311–23. June 2007. doi:10.1016/j.cell.2007.05.022. PMID 17604720. 

Further reading

External links