Biology:TRAF interacting protein
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TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[1][2]
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[2]
Interactions
TRAF interacting protein has been shown to interact with FLII,[3] TRAF1[1] and TRAF2.[1]
References
- ↑ 1.0 1.1 1.2 "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". The Journal of Experimental Medicine 185 (7): 1275–85. April 1997. doi:10.1084/jem.185.7.1275. PMID 9104814.
- ↑ 2.0 2.1 "Entrez Gene: TRAIP TRAF interacting protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10293.
- ↑ "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research 26 (15): 3460–7. August 1998. doi:10.1093/nar/26.15.3460. PMID 9671805.
Further reading
- "Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease". Inflammatory Bowel Diseases 14 (4): 500–7. April 2008. doi:10.1002/ibd.20365. PMID 18200509.
- "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor". The Journal of Experimental Medicine 198 (12): 1959–64. December 2003. doi:10.1084/jem.20031187. PMID 14676304.
- "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research 26 (15): 3460–7. August 1998. doi:10.1093/nar/26.15.3460. PMID 9671805.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- TRAIP human gene location in the UCSC Genome Browser.
- TRAIP human gene details in the UCSC Genome Browser.
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