Biology:PPP2R2C
 Generic protein structure example |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[1][2][3]
Function
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research 6 (5): 323–7. Oct 1999. doi:10.1093/dnares/6.5.323. PMID 10574460.
- ↑ "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics 67 (1): 83–6. Jul 2000. doi:10.1006/geno.2000.6219. PMID 10945473.
- ↑ 3.0 3.1 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522.
Further reading
- "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology 60 (8): 1225–35. Oct 2000. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
- "The role of Vpr in HIV-1 pathogenesis". Current HIV Research 3 (1): 43–51. Jan 2005. doi:10.2174/1570162052772988. PMID 15638722.
- "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. 2006. doi:10.1186/1742-4690-2-11. PMID 15725353.
- "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. Mar 2005. doi:10.1038/sj.cr.7290279. PMID 15780175.
- "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. Apr 2005. PMID 15817944.
- "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2–3): 197–201. Jan 1997. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. Nov 1997. doi:10.1006/viro.1997.8873. PMID 9400615.
- "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". The Journal of Comparative Neurology 392 (4): 515–27. Mar 1998. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. Sep 2001. doi:10.1006/viro.2001.1007. PMID 11531413.
- "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research 30 (14): 3163–70. Jul 2002. doi:10.1093/nar/gkf428. PMID 12136098.
- "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". The Journal of Biological Chemistry 278 (42): 40829–36. Oct 2003. doi:10.1074/jbc.M308678200. PMID 12912990.
- "Identification of specific PP2A complexes involved in human cell transformation". Cancer Cell 5 (2): 127–36. Feb 2004. doi:10.1016/S1535-6108(04)00026-1. PMID 14998489.
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