Biology:TRAF4
 Generic protein structure example |
TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.[1][2][3]
TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins.[4] TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.[5]
Protein interactions
TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1),[6][7] and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.[3]
A recent report indicates that TRAF4 binds to NOD-Like Receptors NOD1 and NOD2, and specifically inhibits activation of NF-κB by the activated NOD2-RIP2 complex [8]
References
- ↑ "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem 270 (43): 25715–21. Dec 1995. doi:10.1074/jbc.270.43.25715. PMID 7592751.
- ↑ "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics 28 (3): 367–76. Jan 1996. doi:10.1006/geno.1995.1163. PMID 7490069.
- ↑ 3.0 3.1 "Entrez Gene: TRAF4 TNF receptor-associated factor 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618.
- ↑ "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. June 2001. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
- ↑ "TRAF4, the unique family member". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 597: 60–71. 2007. doi:10.1007/978-0-387-70630-6_5. ISBN 978-0-387-70629-0. PMID 17633017.
- ↑ "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. October 1999. doi:10.1074/jbc.274.42.30202. PMID 10514511.
- ↑ "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues". Am. J. Pathol. 152 (6): 1549–61. June 1998. PMID 9626059.
- ↑ "A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses". J. Biol. Chem. 286 (3): 1938–1950. 2011. doi:10.1074/jbc.M110.189308. PMID 21097508.
Further reading
- "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene 20 (44): 6482–91. 2001. doi:10.1038/sj.onc.1204788. PMID 11607847.
- "Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development". Mech. Dev. 71 (1–2): 187–91. 1998. doi:10.1016/S0925-4773(97)00192-5. PMID 9507120.
- "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. 2001. doi:10.1074/jbc.M100354200. PMID 11279055.
- "Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5585–90. 2002. doi:10.1073/pnas.052124799. PMID 11943846. Bibcode: 2002PNAS...99.5585R.
- "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. 2002. doi:10.1074/jbc.M202665200. PMID 12023963.
- "Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)". Eur. J. Biochem. 269 (19): 4819–29. 2002. doi:10.1046/j.1432-1033.2002.03180.x. PMID 12354113.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene". J. Biol. Chem. 278 (38): 36435–44. 2003. doi:10.1074/jbc.M303191200. PMID 12788948.
- "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase". Leuk. Res. 27 (8): 687–94. 2003. doi:10.1016/S0145-2126(02)00325-9. PMID 12801526.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells". Blood 106 (6): 2002–10. 2005. doi:10.1182/blood-2004-04-1622. PMID 15941918.
- "TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF". Eur. J. Immunol. 35 (8): 2477–85. 2005. doi:10.1002/eji.200526151. PMID 16052631.
- "MEKK4 is an effector of the embryonic TRAF4 for JNK activation". J. Biol. Chem. 280 (43): 35793–6. 2006. doi:10.1074/jbc.C500260200. PMID 16157600.
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