Biology:UBQLN1
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Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.[1][2][3]
Ubiquilins contain two domains, an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.
Functions
Ubiquilin-1 is associated with protein degradation and aggregation of misfolded proteins, and may be involved in neurodegenerative diseases.[4][5] Ubiquilin-1 has been reported to act as a molecular chaperone for amyloid precursor protein (APP), a protein associated with Alzheimer's disease.[6]
Ubiquilin-1 was first identified through its interactions with presenilins.[7] Two transcript variants encoding different isoforms have been found for this gene.[3]
Related proteins
Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.[8]
Interactions
UBQLN1 has been shown to interact with
References
- ↑ "Identification of a new cellular protein that can interact specifically with DAN". DNA and Cell Biology 16 (8): 985–91. August 1997. doi:10.1089/dna.1997.16.985. PMID 9303440.
- ↑ "Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3". Journal of Human Genetics 45 (3): 188–91. Jul 2000. doi:10.1007/s100380050209. PMID 10807547.
- ↑ 3.0 3.1 "Entrez Gene: UBQLN1 ubiquilin 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979.
- ↑ "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions 38 (Pt 1): 150–5. February 2010. doi:10.1042/BST0380150. PMID 20074050.
- ↑ "An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis". Discovery Medicine 8 (40): 18–22. June 2009. PMID 19772837.
- ↑ "Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein". The Journal of Biological Chemistry 286 (41): 35689–98. October 2011. doi:10.1074/jbc.M111.243147. PMID 21852239.
- "Alzheimer's brains found to have lower levels of key protein". ScienceDaily (Press release). September 1, 2011.
- ↑ "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology 151 (4): 847–62. November 2000. doi:10.1083/jcb.151.4.847. PMID 11076969.
- ↑ "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evolutionary Biology 14: 63. March 2014. doi:10.1186/1471-2148-14-63. PMID 24674348.
- ↑ "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications 369 (2): 741–6. May 2008. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982.
- ↑ "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1542 (1–3): 41–56. January 2002. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.
- ↑ "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". The Journal of Biological Chemistry 277 (38): 35386–92. September 2002. doi:10.1074/jbc.M203412200. PMID 12095988.
- ↑ 12.0 12.1 "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology 151 (4): 847–62. November 2000. doi:10.1083/jcb.151.4.847. PMID 11076969.
- ↑ "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Molecular Cell 6 (2): 409–19. August 2000. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.
- ↑ "A proteome-scale map of the human interactome network". Cell 159 (5): 1212–1226. November 2014. doi:10.1016/j.cell.2014.10.050. PMID 25416956.
Further reading
- "Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5)". Biochemical and Biophysical Research Communications 237 (2): 245–50. August 1997. doi:10.1006/bbrc.1997.7122. PMID 9268694.
- "Cloning and characterization of rat BAT3 cDNA". DNA and Cell Biology 18 (6): 503–12. June 1999. doi:10.1089/104454999315222. PMID 10390159.
- "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane". Molecular Cell 4 (4): 619–25. October 1999. doi:10.1016/S1097-2765(00)80212-9. PMID 10549293.
- "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Molecular Cell 6 (2): 409–19. August 2000. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.
- "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology 151 (4): 847–62. November 2000. doi:10.1083/jcb.151.4.847. PMID 11076969.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. September 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1". Nature Neuroscience 4 (9): 908–16. September 2001. doi:10.1038/nn0901-908. PMID 11528422.
- "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1542 (1–3): 41–56. January 2002. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.
- "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". The Journal of Biological Chemistry 277 (38): 35386–92. September 2002. doi:10.1074/jbc.M203412200. PMID 12095988.
- "Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase". Journal of Virology 77 (7): 4149–59. April 2003. doi:10.1128/JVI.77.7.4149-4159.2003. PMID 12634373.
- "Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins". Journal of Alzheimer's Disease 6 (1): 79–92. February 2004. doi:10.3233/jad-2004-6109. PMID 15004330.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. July 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". International Journal of Oncology 25 (5): 1213–21. November 2004. doi:10.3892/ijo.25.5.1213. PMID 15492808.
- "Family-based association between Alzheimer's disease and variants in UBQLN1". The New England Journal of Medicine 352 (9): 884–94. March 2005. doi:10.1056/NEJMoa042765. PMID 15745979.
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