Biology:PICK1
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Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.[1][2]
Function
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.[3]
Interactions
PICK1 has been shown to interact with:
- ACCN2,[4][5]
- BNC1,[5]
- Dopamine transporter,[6]
- GRIA2,[7]
- GRIA3,[7]
- GRIA4,[7]
- GRIK1,[8]
- GRIK2,[8]
- GRIK3,[7]
- HER2/neu,[9]
- Metabotropic glutamate receptor 3,[7] and
- Metabotropic glutamate receptor 7.[10]
References
- ↑ "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology 38 (5): 635–44. July 1999. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301.
- ↑ "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- ↑ "Entrez Gene: PICK1 protein interacting with PRKCA 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9463.
- ↑ "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. February 2003. doi:10.1073/pnas.252782799. PMID 12578970.
- ↑ 5.0 5.1 "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. February 2002. doi:10.1042/0264-6021:3610443. PMID 11802773.
- ↑ "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. April 2001. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.
- ↑ 7.0 7.1 7.2 7.3 7.4 "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. May 2002. doi:10.1074/jbc.C200112200. PMID 11891216.
- ↑ 8.0 8.1 "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron 37 (4): 625–38. February 2003. doi:10.1016/s0896-6273(02)01191-1. PMID 12597860.
- ↑ "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. May 2001. doi:10.1074/jbc.M010032200. PMID 11278603.
- ↑ "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. October 2000. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMID 11007882.
Further reading
- "Functional roles of protein interactions with AMPA and kainate receptors". Neurosci. Res. 47 (1): 3–15. 2003. doi:10.1016/S0168-0102(03)00160-3. PMID 12941441.
- "Structure and function of PICK1". Neurosignals 15 (4): 190–201. 2006. doi:10.1159/000098482. PMID 17215589.
- "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system". J. Cell Biol. 128 (3): 263–71. 1995. doi:10.1083/jcb.128.3.263. PMID 7844141. PMC 2120344. https://kuscholarworks.ku.edu/bitstream/1808/17706/1/StaudingerJ_JCB_128%283%29263.pdf.
- "Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha". J. Biol. Chem. 272 (51): 32019–24. 1998. doi:10.1074/jbc.272.51.32019. PMID 9405395.
- "Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1". Neuron 22 (1): 179–87. 1999. doi:10.1016/S0896-6273(00)80689-3. PMID 10027300.
- "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron 21 (6): 1453–63. 1999. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737.
- "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors". Biochem. Biophys. Res. Commun. 267 (1): 149–55. 2000. doi:10.1006/bbrc.1999.1932. PMID 10623590.
- "EphB2 guides axons at the midline and is necessary for normal vestibular function". Neuron 26 (2): 417–30. 2000. doi:10.1016/S0896-6273(00)81174-5. PMID 10839360.
- "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. 2001. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMID 11007882.
- "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1". Biochem. J. 354 (Pt 3): 635–43. 2001. doi:10.1042/0264-6021:3540635. PMID 11237868.
- "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. 2001. doi:10.1074/jbc.M010032200. PMID 11278603. http://prodinra.inra.fr/ft/1478A66C-AC9E-4818-B9CC-97753E19BBE6.
- "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. 2001. doi:10.1016/S0896-6273(01)00267-7. PMID 11343649.
- "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. 2001. doi:10.1124/mol.60.5.916. PMID 11641419. https://semanticscholar.org/paper/412e1319fa7fdf68654f055e616b63a16736429a.
- "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. 2002. doi:10.1074/jbc.M104748200. PMID 11739374.
- "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. 2002. doi:10.1042/0264-6021:3610443. PMID 11802773.
- "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. 2002. doi:10.1074/jbc.C200112200. PMID 11891216.
- "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7". EMBO J. 21 (12): 2990–9. 2002. doi:10.1093/emboj/cdf313. PMID 12065412.
- "PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system". J. Comp. Neurol. 517 (3): 313–322. 2009. doi:10.1002/cne.22155. PMID 19757495.
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