Medicine:Collecting duct carcinoma

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Short description: Type of kidney cancer
Collecting duct carcinoma
Other namesBellini duct carcinoma[1]
File:Collecting duct carcinoma - 2 WBAL.tif
Collecting duct carcinoma. H&E stain.
SpecialtyOncology/nephrology
Collecting duct carcinoma in computed tomography

Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.[2] It is also recently described; a 2002 review found just 40 case reports worldwide.[3] Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.[4] However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly.

Signs and symptoms

Signs and symptoms are as for kidney cancer.[citation needed]

Histology

Histologic examination of collecting duct carcinoma demonstrates an infiltrative lesion with tubulopapillary, irregular channels lined by high grade hobnail cells with marked desmoplastic response and brisk neutrophilic infiltrate.[citation needed]

Treatment

History

CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.[5]

References

  1. ↑ "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma". Am. J. Surg. Pathol. 33 (3): 384–92. March 2009. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562. 
  2. ↑ "Major response and clinical benefit following third-line treatment for Bellini duct carcinoma". Wien. Klin. Wochenschr. 117 (1–2): 63–5. January 2005. doi:10.1007/s00508-004-0289-4. PMID 15986594. 
  3. ↑ "Bellini duct carcinoma: review of diagnosis and management". Int Urol Nephrol 34 (1): 91–5. 2002. doi:10.1023/A:1021315130481. PMID 12549647. http://www.kluweronline.com/art.pdf?issn=0301-1623&volume=34&page=91. 
  4. ↑ "Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma?". J. Urol. 169 (4): 1287–90. April 2003. doi:10.1097/01.ju.0000050221.51509.f5. PMID 12629344. 
  5. ↑ O Natsume; S Ozono; T Futami; M Ohta (1997). "Bellini duct carcinoma: a case report". Japanese Journal of Clinical Oncology 27 (2): 107–110. doi:10.1093/jjco/27.2.107. PMID 9152800. 

External links

Classification
External resources



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