Medicine:Vaso-occlusive crisis
| Vaso-occlusive crisis | |
|---|---|
| Specialty | Angiology |
| Symptoms | acute, severe pain |
| Diagnostic method | There is no test to confirm a vaso-occlusive crisis, but tests can be done to rule out other causes. Patients with vaso-occlusive crisis present with pain (mild to severe) and a history of sickle cell anemia. |
| Differential diagnosis | Neuropathic pain, hyperalgesia, osteomyelitis |
A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults.[1][2] It is a form of sickle cell crisis. Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries. The most common complaint is of pain, and recurrent episodes may cause irreversible organ damage.[2] One of the most severe forms is the acute chest syndrome which occurs as a result of infarction of the lung parenchyma. This can rapidly result in death. Other types of vaso-occlusive crisis in sickle cell anemia include dactylitis, priapism, abdominal pain, and jaundice.
Diagnosis
Diagnosis of vaso-occlusive crisis is based on clinical manifestations, complete blood count with white blood cell differential, platelet count, reticulocyte count, and comprehensive metabolic panel with liver and kidney function tests.[3] Typical lab findings include acute drop in hemoglobin concentration, increased platelet count, increased reticulocyte count, and elevated serum urea.[4]
Management
The management of an acute event of vaso-occlusive crisis is the use of potent analgesics (opioids),[5] rehydration with normal saline or Ringer's lactate, treatment of malaria (whether symptomatic or not) using artemisinin combination therapy, and the use of oxygen via face mask, especially for acute chest syndrome. Hyperbaric oxygen has also been shown to be a useful adjunct in pain reduction.[6]
References
- ↑ "Sickle-cell disease". Lancet 364 (9442): 1343–60. 2004. doi:10.1016/S0140-6736(04)17192-4. PMID 15474138.
- ↑ 2.0 2.1 "The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database". Am. J. Hematol. 85 (10): 797–9. October 2010. doi:10.1002/ajh.21807. PMID 20730795.
- ↑ YAWN, BARBARA P.; JOHN-SOWAH, JOYLENE (15 December 2015). "Management of Sickle Cell Disease: Recommendations from the 2014 Expert Panel Report". American Family Physician 92 (12): 1069–1076A. PMID 26760593. https://www.aafp.org/afp/2015/1215/p1069.html.
- ↑ Rees, David C.; Gibson, John S. (28 November 2011). "Biomarkers in sickle cell disease" (in en). British Journal of Haematology 156 (4): 433–445. doi:10.1111/j.1365-2141.2011.08961.x. PMID 22122125.
- ↑ "Treatment of the acute sickle cell vaso-occlusive crisis in the Emergency Department: a Brazilian method of switching from intravenous to oral morphine". Eur. J. Haematol. 93 (1): 34–40. July 2014. doi:10.1111/ejh.12293. PMID 24571671.
- ↑ "Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease". Diving Hyperb Med 42 (2): 82–4. June 2012. PMID 22828815. http://archive.rubicon-foundation.org/10424. Retrieved 2014-07-06.
External links
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