Chemistry:Ponsegromab
From HandWiki
| Monoclonal antibody | |
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| Type | ? |
| Target | GDF-15 |
| Clinical data | |
| Other names | PF-06946860 |
| Legal status | |
| Legal status |
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| Identifiers | |
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Ponsegromab (PF-06946860) is a monoclonal antibody that works as a GDF-15 inhibitor. It is developed by Pfizer for cancer cachexia.[1][2][3][4][5]
References
- ↑ Nishie, Kenichi; Nishie, Tomomi; Sato, Seiichi; Hanaoka, Masayuki (September 2023). "Update on the treatment of cancer cachexia". Drug Discovery Today 28 (9): 103689. doi:10.1016/j.drudis.2023.103689. PMID 37385369.
- ↑ Roeland, E.J.; Yennu, S.; Del Fabbro, E.; Buckeridge, C.; Thayer, K.M.; Collins, S.M.; Lubaczewski, S.L.; Wang, E.Q. et al. (September 2021). "1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer". Annals of Oncology 32: S1185. doi:10.1016/j.annonc.2021.08.1668.
- ↑ Crawford, Jeffrey; Lubaczewski, Shannon L; Tarachandani, Anil; Harrington, Magdalena A; Weng, Yan; Qiu, Ruolun; Collins, Susie M; Rossulek, Michelle I et al. (1 June 2023). "Phase 2 study to assess the efficacy, safety, and tolerability of the GDF-15 inhibitor ponsegromab in patients with cancer cachexia.". Journal of Clinical Oncology 41 (16_suppl): TPS12147. doi:10.1200/JCO.2023.41.16_suppl.TPS12147.
- ↑ Crawford, Jeffrey; Calle, Roberto A.; Collins, Susie M.; Weng, Yan; Lubaczewski, Shannon L.; Buckeridge, Clare; Wang, Ellen Q.; Harrington, Magdalena A. et al. (14 April 2023). "Abstract CT108: First-in-patient study of the GDF-15 inhibitor ponsegromab in patients with cancer and cachexia: Safety, tolerability, and exploratory measures of efficacy". Cancer Research 83 (8_Supplement): CT108. doi:10.1158/1538-7445.AM2023-CT108.
- ↑ Talbert, Erin E.; Guttridge, Denis C. (May 2022). "Emerging signaling mediators in the anorexia–cachexia syndrome of cancer". Trends in Cancer 8 (5): 397–403. doi:10.1016/j.trecan.2022.01.004. PMID 35190301.
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