Chemistry:Galnon
From HandWiki
Short description: Chemical compound
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| Formula | C40H46N4O6 |
| Molar mass | 678.815 g·mol−1 |
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Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]
References
- ↑ "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. May 2002. doi:10.1073/pnas.102163499. PMID 12011470. Bibcode: 2002PNAS...99.7136S.
- ↑ "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides 39 (3): 161–3. June 2005. doi:10.1016/j.npep.2004.12.019. PMID 15944006.
- ↑ "Regulation of feeding by galnon". Neuropeptides 38 (1): 55–61. February 2004. doi:10.1016/j.npep.2004.01.001. PMID 15003717.
- ↑ "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. June 2005. doi:10.1016/j.npep.2004.12.010. PMID 15944018.
- ↑ "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides 41 (5): 307–20. October 2007. doi:10.1016/j.npep.2007.05.001. PMID 17637475.
- ↑ "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry 65 (5): 383–91. March 2009. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221.
- ↑ "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology 204 (1): 95–102. May 2009. doi:10.1007/s00213-008-1438-7. PMID 19099295.
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