Chemistry:LB54640
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LB54640 is a small molecule melanocortin 4 receptor agonist developed by LG Chem Life Sciences for hypothalamic obesity. Unlike the older drug with the same mechanism of action, setmelanotide, it can be taken by mouth.[1][2][3]
References
- ↑ Aronne, Sarah R. Barenbaum, Louis J. (2023). "Antiobesity Medications on the Horizon". Handbook of Obesity - Volume 2 (5 ed.). CRC Press. pp. 394–401. doi:10.1201/9781003432807-42. ISBN 978-1-003-43280-7. https://www.taylorfrancis.com/chapters/edit/10.1201/9781003432807-42/antiobesity-medications-horizon-sarah-barenbaum-louis-aronne.
- ↑ First-in-Human Study of Safety, Pharmacodynamics of LB54640, An Oral Melanocortin-4 Receptor Agonist Mirza, Victoria, MD, MPH; Lee, Jisoo, MD; Gwak, Heemin; Yang, Yunjeong; Kim, Mina. Obesity; Silver Spring Vol. 30, (Nov 2022): 145-146.
- ↑ Piper, Noah B.C.; Whitfield, Emily A.; Stewart, Gregory D.; Xu, Xiaomeng; Furness, Sebastian G.B. (August 2022). "Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors". Biochemical Pharmacology 202: 115115. doi:10.1016/j.bcp.2022.115115. PMID 35671790.
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