Chemistry:May–Grünwald stain

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May Grünwald–Giemsa staining of bone marrow cells taken from a patient with hereditary folate malabsorption, from a case report by Yukari Sakurai et al., 2022[1]

May–Grünwald stain is used for the staining of slides obtained by fine-needle aspiration in a histopathology lab for the diagnosis of tumorous cells.[2][3]

Sometimes, it is combined with Giemsa staining, yielding Pappenheim staining (May-Grünwald-Giemsa staining).[4]

References

  1. Sakurai, Y., Toriumi, N., Sarashina, T. et al. An infantile case of hereditary folate malabsorption with sudden development of pulmonary hemorrhage: a case report. J Med Case Reports 16, 268 (2022). https://doi.org/10.1186/s13256-022-03448-x
  2. Harald Kluge (2007). Atlas of CSF Cytology. Thieme. p. 4. ISBN 978-3-13-143161-5. https://books.google.com/books?id=HDLv-LAfqHoC&pg=PA4. 
  3. Giorgio Gherardi (14 August 2010). Fine-Needle Biopsy of Superficial and Deep Masses: Interventional Approach and Interpretation Methodology by Pattern Recognition. Springer Science & Business Media. p. 10. ISBN 978-88-470-1433-6. https://books.google.com/books?id=GygP-r1pOW4C&pg=PA10. 
  4. "May-Gruenwald solution". https://www.biognost.com/product/may-gruenwald-solution/.