Biography:Parastoo Hashemi
Parastoo ("Parry") Hashemi (born 1980) is an Iranian-British neural engineer at Imperial College London.
Hashemi's research develops and applies sensors for brain measurements of neurotransmitters in the context of mental illness etiology, diagnosis and treatment.[1][2]
Life and academic career
Early life
Hashemi was born in Tehran, Iran and immigrated with her family to the United Kingdom, as a child, in 1986. She grew up in Durham, UK and attended Belmont Comprehensive school and Durham Johnston 6th Form College.
Hashemi graduated with a first class Master in Science (MSci) degree in chemistry from King's College London in 2003.[2] She received her PhD in Bioengineering from Imperial College London in 2007 under the mentorship of Dr. Martyn Boutelle.[2][3] The focus of her Ph.D. research was to develop online microdialysis techniques for monitoring humans with traumatic brain injury.[2]
Hashemi moved to the United States in 2007 to perform her post-doctoral work with Dr. R. Mark Wightman at the University of North Carolina at Chapel Hill.[2][3] The focus of her post-doctoral research was to develop a selective method for in vivo detection for brain serotonin.[2][4]
Positions held
Hashemi held an assistant professorship in the department of Chemistry at Wayne State University[2] from 2011 to 2015 and in the department of Chemistry and Biochemistry at the University of South Carolina[2] from 2015-2022 where she was tenured in 2017. Hashemi continues to run her lab as a Reader in Brain Diagnostics and Therapeutics in the Department of Bioengineering at Imperial College London[5] since 2019.[6]
Research
Hashemi has pioneered tools for measurements of serotonin in the brain,[2][7][8][9] a neurotransmitter important in the pathology of depression. Her team is using these tools in a variety of models to better understand, diagnose and treat mental disorders, with a focus on depression.[10]
Notable awards
- 2019 CAMS Fellow (Community for Analytical Measurement Science)
- 2018 Society for Electroanalytical Chemistry (SEAC) Royce W. Murray Award[11]
- 2018 Society of Pittsburgh Chemists Pittcon Achievement Award[12]
- 2018 USC Breakthrough Stars Award[13]
- 2017 Midwestern Universities Analytical Chemistry Conference Young Investigator Travel Award
- 2017 International Society for Neurochemistry Brain in Flux Symposium Young Faculty Travel Award
- 2017 NSF CAREER Award[14]
- 2015 Eli Lilly Young Investigator Award in Analytical Chemistry
- 2013 Masao Horiba Award for Analytical Chemistry[15]
Notable papers
- Hersey, Melinda; Samaranayake, Srimal; Berger, Shane N.; Tavakoli, Navid; Mena, Sergio; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet et al. (2021-07-28). "Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin" (in en). Journal of Neuroscience 41 (30): 6564–6577. doi:10.1523/JNEUROSCI.2618-20.2021. ISSN 0270-6474. PMID 34083254.
- West, Alyssa; Best, Janet; Abdalla, Aya; Nijhout, H. Frederik; Reed, Michael; Hashemi, Parastoo (2019-02-01). "Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex" (in en). Neurochemistry International. Brain in Flux-III 123: 50–58. doi:10.1016/j.neuint.2018.07.004. ISSN 0197-0186. PMID 30031052.
- Abdalla, Aya; West, Alyssa; Jin, Yunju; Saylor, Rachel A.; Qiang, Beidi; Peña, Edsel; Linden, David J.; Nijhout, H. Frederik et al. (2020). "Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology" (in en). Journal of Neurochemistry 153 (1): 33–50. doi:10.1111/jnc.14854. ISSN 1471-4159. PMID 31419307.
- Jin, Yunju; Dougherty, Sarah E.; Wood, Kevin; Sun, Landy; Cudmore, Robert H.; Abdalla, Aya; Kannan, Geetha; Pletnikov, Mikhail et al. (2016-08-17). "Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury" (in en). Neuron 91 (4): 748–762. doi:10.1016/j.neuron.2016.07.024. ISSN 0896-6273. PMID 27499084.
- Atcherley, Christopher W.; Wood, Kevin M.; Parent, Kate L.; Hashemi, Parastoo; Heien, Michael L. (2015-01-27). "The coaction of tonic and phasic dopamine dynamics" (in en). Chemical Communications 51 (12): 2235–2238. doi:10.1039/C4CC06165A. ISSN 1364-548X. PMID 25249291.
References
- ↑ "Parastoo Hashemi: Tackling Complex Biological and Environmental Problems". 2 March 2017. https://www.huffpost.com/entry/parastoo-hashemi-tackling-complex-biological-and-environmental_b_58b82b2ce4b0e9d19b9265b1.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 "CV of Parastoo Hashemi". https://sc.edu/study/colleges_schools/chemistry_and_biochemistry/docs/faculty_docs/hashemi_parastoo/hashemi_cv_2018.pdf.
- ↑ 3.0 3.1 "Chemistry Tree - Parastoo Hashemi Family Tree". https://academictree.org/chemistry/tree.php?pid=746098.
- ↑ Hashemi, Parastoo; Dankoski, Elyse C.; Petrovic, Jelena; Keithley, Richard B.; Wightman, R. Mark (2009). "Voltammetric Detection of 5-Hydroxytryptamine Release in the Rat Brain". Analytical Chemistry 81 (22): 9462–9471. doi:10.1021/ac9018846. PMID 19827792.
- ↑ "Academic staff and research fellows | Faculty of Engineering | Imperial College London". https://www.imperial.ac.uk/bioengineering/people/academic-staff-and-research-fellows/.
- ↑ "The Bioengineering Immuno-Pathology Network at Imperial College London". 25 January 2024. https://www.imperial.ac.uk/immunopathology-network/research/bioengineering/.
- ↑ Wood, Kevin M.; Zeqja, Anisa; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Hashemi, Parastoo (2014). "Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo" (in en). Journal of Neurochemistry 130 (3): 351–359. doi:10.1111/jnc.12733. ISSN 1471-4159. PMID 24702305.
- ↑ Abdalla, Aya; Atcherley, Christopher W.; Pathirathna, Pavithra; Samaranayake, Srimal; Qiang, Beidi; Peña, Edsel; Morgan, Stephen L.; Heien, Michael L. et al. (2017-09-07). "In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes". Analytical Chemistry 89 (18): 9703–9711. doi:10.1021/acs.analchem.7b01257. ISSN 0003-2700. PMID 28795565.
- ↑ Saylor, Rachel A.; Hersey, Melinda; West, Alyssa; Buchanan, Anna Marie; Berger, Shane N.; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet et al. (2019). "In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry". Frontiers in Neuroscience 13: 362. doi:10.3389/fnins.2019.00362. ISSN 1662-453X. PMID 31110471.
- ↑ Hersey, Melinda; Samaranayake, Srimal; Berger, Shane N.; Tavakoli, Navid; Mena, Sergio; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet et al. (2021-07-28). "Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin" (in en). Journal of Neuroscience 41 (30): 6564–6577. doi:10.1523/JNEUROSCI.2618-20.2021. ISSN 0270-6474. PMID 34083254. PMC 8318079. https://www.jneurosci.org/content/41/30/6564.
- ↑ "Awards Information - Charles N. Reilley, Y.I., and Travel". http://electroanalytical.org/awards.html#previous/.
- ↑ "Pittcon Announces 2018 Award Recipients for Outstanding Achievements in Analytical Chemistry and Applied Spectroscopy". 2 October 2017. https://pittcon.org/pittcon-announces-2018-award-recipients-outstanding-achievements-analytical-chemistry-applied-spectroscopy/.
- ↑ "2018 Breakthrough Awards Cover the Academic Spectrum - Office of the Vice President for Research | University of South Carolina". https://sc.edu/about/offices_and_divisions/research/news_and_pubs/breakthrough_magazine/2018_breakthrough_awards.php.
- ↑ "NSF Award Search: Award#1654111 - CAREER: The fundamental principles of modified carbon fiber microelectrodes as speciation sensors". https://nsf.gov/awardsearch/showAward?AWD_ID=1654111&HistoricalAwards=false.
- ↑ "2013 | Masao Horiba Awards / 堀場雅夫賞". http://www.mh-award.org/en/year/2013/.
External links
- Parastoo Hashemi- UofSC Chemistry and Biochemsitry
- Parastoo Hashemi- Imperial College London Bioengineering
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