Biography:Renata Basto

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Short description: Researcher

Renata Homem de Gouveia Xavier de Basto is a researcher in cell and developmental biology. She is currently a team leader at the Institut Curie in Paris. She is also the deputy director of the CNRS research Unit UMR144 'Cell biology and cancer'[1] at the Institut Curie which, comprises 14 research teams.

Education and academic appointments

Renata Basto was born on December 17, 1972, in Mozambique.[2] She did her undergraduate studies in biology and genetics at the University of Lisbon in Portugal.[2][3][4] She then did her PhD in the lab of Roger Karess in Paris. In 2002, she joined the laboratory of Jordan Raff in Cambridge (UK) to do her postdoctoral studies.[5] In 2007, she was recruited at the CNRS and started her own research team in 2008 at the Institut Curie.[3] In addition to running her own research group, she became the deputy director of the research Unit UMR144 'Cell biology and cancer'.[1]

Research

During her PhD, Renata Basto studied the control of the transition from metaphase to anaphase in Drosophila.[6]

During her postdoc in the lab of Jordan Raff, Renata Basto investigated the role of centrioles in flies during development. Her work led to two publications in the highly recognized journal Cell, which have been cited more than 600 and 400 times respectively since publication.[7][8]

With her team she continued investigating the biology of centrosomes and the consequences of genetic instabilities.[9] She has published research on centrosome biology[10][11] and has also investigated the role of aneuploidy, polyploidy and genetic instability.[12][13][14]

She is considered a reference in the field of centrosomes biology and has edited a book about methods to study cilia and flagella.[15] She is the author of 58 publications and has been cited 1,929 times.[16]

Awards

  • 2009 – ERC starting grant[17][18]
  • 2016 – ERC consolidator grant[17]

References

  1. ↑ 1.0 1.1 "Cell dynamics research: Institut Curie, subcellular structure and cellular dynamics" (in en-US). https://science.institut-curie.org/research/multiscale-physics-biology-chemistry/umr144-subcellular-structure-and-cellular-dynamics/. 
  2. ↑ 2.0 2.1 "Renata Homem de Gouveia Xavier de BASTO". https://www.barrosbrito.com/7127.html. 
  3. ↑ 3.0 3.1 "Renata Basto | INSU". https://www.insu.cnrs.fr/fr/personne/renata-basto. 
  4. ↑ "Renata Homem de Gouveia Xavier de Basto" (in en). https://arquivo.fct.pt/details?id=84209. 
  5. ↑ "Previous Lab Members | Raff Lab". http://www2.bioch.ox.ac.uk/nanogroup/rafflab_alumni.html. 
  6. ↑ Basto, Renata; Gomes, Rui; Karess, Roger E. (December 2000). "Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila" (in en). Nature Cell Biology 2 (12): 939–943. doi:10.1038/35046592. ISSN 1476-4679. PMID 11146659. https://www.nature.com/articles/ncb1200_939. 
  7. ↑ Basto, Renata; Lau, Joyce; Vinogradova, Tatiana; Gardiol, Alejandra; Woods, C. Geoffrey; Khodjakov, Alexey; Raff, Jordan W. (2006-06-30). "Flies without Centrioles" (in en). Cell 125 (7): 1375–1386. doi:10.1016/j.cell.2006.05.025. ISSN 0092-8674. PMID 16814722. 
  8. ↑ Basto, Renata; Brunk, Kathrin; Vinadogrova, Tatiana; Peel, Nina; Franz, Anna; Khodjakov, Alexey; Raff, Jordan W. (2008-06-13). "Centrosome Amplification Can Initiate Tumorigenesis in Flies" (in en). Cell 133 (6): 1032–1042. doi:10.1016/j.cell.2008.05.039. ISSN 0092-8674. PMID 18555779. 
  9. ↑ "Biology of centrosomes and genetic instability" (in en-US). https://science.institut-curie.org/research/multiscale-physics-biology-chemistry/umr144-subcellular-structure-and-cellular-dynamics/team-basto/. 
  10. ↑ Marthiens, Véronique; Rujano, Maria A.; Pennetier, Carole; Tessier, Sarah; Paul-Gilloteaux, Perrine; Basto, Renata (2013-05-12). "Centrosome amplification causes microcephaly". Nature Cell Biology 15 (7): 731–740. doi:10.1038/ncb2746. ISSN 1465-7392. PMID 23666084. 
  11. ↑ Gambarotto, Davide; Pennetier, Carole; Ryniawec, John M.; Buster, Daniel W.; Gogendeau, Delphine; Goupil, Alix; Nano, Maddalena; Simon, Anthony et al. (2019-07-01). "Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells" (in en). Developmental Cell 50 (1): 11–24.e10. doi:10.1016/j.devcel.2019.04.036. ISSN 1534-5807. PMID 31130353. 
  12. ↑ Gogendeau, Delphine; Siudeja, Katarzyna; Gambarotto, Davide; Pennetier, Carole; Bardin, Allison J.; Basto, Renata (2015-11-17). "Aneuploidy causes premature differentiation of neural and intestinal stem cells" (in en). Nature Communications 6 (1): 8894. doi:10.1038/ncomms9894. ISSN 2041-1723. PMID 26573328. 
  13. ↑ Nano, Maddalena; Gemble, Simon; Simon, Anthony; Pennetier, Carole; Fraisier, Vincent; Marthiens, Veronique; Basto, Renata (2019-11-18). "Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells" (in en). Current Biology 29 (22): 3937–3945.e7. doi:10.1016/j.cub.2019.09.041. ISSN 0960-9822. PMID 31708395. 
  14. ↑ Goupil, Alix; Nano, Maddalena; Letort, Gaëlle; Gemble, Simon; Edwards, Frances; Goundiam, Oumou; Gogendeau, Delphine; Pennetier, Carole et al. (2020-04-06). "Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells" (in en). Journal of Cell Biology 219 (4). doi:10.1083/jcb.201908006. ISSN 0021-9525. PMID 32328633. 
  15. ↑ (in en) Methods in Cilia and Flagella. Academic Press. 2015-03-26. ISBN 978-0-12-802640-3. https://books.google.com/books?id=5-CoBAAAQBAJ&q=%22renata+basto%22+cilia+book&pg=PP1. 
  16. ↑ "Renata Basto | Semantic Scholar" (in en-US). https://www.semanticscholar.org/author/Renata-Basto/6610809. 
  17. ↑ 17.0 17.1 "ERC FUNDED PROJECTS" (in en). https://erc.europa.eu/projects-figures/erc-funded-projects/results. 
  18. ↑ "EU research". https://cordis.europa.eu/project/id/242598. 



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