Chemistry:NED-19
From HandWiki
Short description: Chemical compound
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| Formula | C30H31FN4O3 |
| Molar mass | 514.601 g·mol−1 |
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Trans-NED-19 is a drug which acts as a potent and selective antagonist of the endogenous calcium channel opener nicotinic acid adenine dinucleotide phosphate (NAADP), thereby reducing the normal NAADP-mediated calcium flux without blocking calcium channels directly. It is used in research into the functions of NAADP signalling inside many different cell types.[1][2][3][4][5][6][7][8]
References
- ↑ "Identification of a chemical probe for NAADP by virtual screening". Nature Chemical Biology 5 (4): 220–6. April 2009. doi:10.1038/nchembio.150. PMID 19234453.
- ↑ "Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor". The Journal of Biological Chemistry 284 (50): 34930–4. December 2009. doi:10.1074/jbc.M109.016519. PMID 19826006.
- ↑ "Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes". The Journal of Biological Chemistry 288 (49): 35548–58. December 2013. doi:10.1074/jbc.M113.489278. PMID 24165120.
- ↑ "CD38 mediates angiotensin II-induced intracellular Ca(2+) release in rat pulmonary arterial smooth muscle cells". American Journal of Respiratory Cell and Molecular Biology 52 (3): 332–41. March 2015. doi:10.1165/rcmb.2014-0141OC. PMID 25078456.
- ↑ "Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore". Cardiovascular Research 108 (3): 357–66. December 2015. doi:10.1093/cvr/cvv226. PMID 26395965.
- ↑ "Glutamate induces autophagy via the two-pore channels in neural cells". Oncotarget 8 (8): 12730–12740. February 2017. doi:10.18632/oncotarget.14404. PMID 28055974.
- ↑ "2+ Homeostasis in Mouse Hippocampal Neurons". Frontiers in Cell and Developmental Biology 8: 496. 2020. doi:10.3389/fcell.2020.00496. PMID 32676502.
- ↑ "Targeting Two-Pore Channels: Current Progress and Future Challenges". Trends in Pharmacological Sciences 41 (8): 582–594. August 2020. doi:10.1016/j.tips.2020.06.002. PMID 32679067.
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