Biology:ARFGEF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.[1][2]
Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.[2]
Interactions
ARFGEF2 has been shown to interact with ARFGEF1,[3] PRKAR1A[4] and PRKAR2A.[4]
References
- ↑ "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry 274 (18): 12308–15. Apr 1999. doi:10.1074/jbc.274.18.12308. PMID 10212200.
- ↑ 2.0 2.1 "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564.
- ↑ "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America 97 (6): 2567–72. Mar 2000. doi:10.1073/pnas.97.6.2567. PMID 10716990. Bibcode: 2000PNAS...97.2567Y.
- ↑ 4.0 4.1 "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America 100 (4): 1627–32. Feb 2003. doi:10.1073/pnas.0337678100. PMID 12571360. Bibcode: 2003PNAS..100.1627L.
External links
- Human ARFGEF2 genome location and ARFGEF2 gene details page in the UCSC Genome Browser.
Further reading
- "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America 97 (6): 2567–72. Mar 2000. doi:10.1073/pnas.97.6.2567. PMID 10716990. Bibcode: 2000PNAS...97.2567Y.
- "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics 69 (1): 113–9. Oct 2000. doi:10.1006/geno.2000.6310. PMID 11013081.
- "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". Methods in Enzymology 345: 397–404. 2002. doi:10.1016/S0076-6879(02)45032-X. ISBN 9780121822460. PMID 11665623.
- "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry 277 (11): 9468–73. Mar 2002. doi:10.1074/jbc.M112427200. PMID 11777925.
- "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications 294 (2): 254–60. Jun 2002. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
- "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America 100 (4): 1627–32. Feb 2003. doi:10.1073/pnas.0337678100. PMID 12571360. Bibcode: 2003PNAS..100.1627L.
- "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nature Genetics 36 (1): 69–76. Jan 2004. doi:10.1038/ng1276. PMID 14647276.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. Jul 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proceedings of the National Academy of Sciences of the United States of America 102 (8): 2784–9. Feb 2005. doi:10.1073/pnas.0409871102. PMID 15705715. Bibcode: 2005PNAS..102.2784X.
- "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology 494 (3): 476–84. Jan 2006. doi:10.1002/cne.20806. PMID 16320251.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". The Journal of Biological Chemistry 282 (13): 9591–9. Mar 2007. doi:10.1074/jbc.M607122200. PMID 17276987.
- "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3201–6. Feb 2007. doi:10.1073/pnas.0611696104. PMID 17360629. Bibcode: 2007PNAS..104.3201K.
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