Biology:DHR2 domain
From HandWiki
Short description: Protein domain
DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins.[1] This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family.[2] DHR2 domains bear no significant similarity to the well described DH domain (Dbl homologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity.
References
- ↑ "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. November 2005. doi:10.1242/jcs.02671. PMID 16254241.
- ↑ "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. December 2002. doi:10.1242/jcs.00219. PMID 12432077.
Further reading
- "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends Cell Biol. 17 (8): 383–393. 2007. doi:10.1016/j.tcb.2007.05.001. PMID 17765544.
- "In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains". Meth. Enzymol.. Methods in Enzymology 406: 41–57. 2006. doi:10.1016/S0076-6879(06)06004-6. ISBN 9780121828110. PMID 16472648.
- "GEF A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs". Curr. Biol. 15 (4): 371–77. 2005. doi:10.1016/j.cub.2005.01.050. PMID 15723800.
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