Biology:DHR2 domain

From HandWiki
Short description: Protein domain

DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins.[1] This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family.[2] DHR2 domains bear no significant similarity to the well described DH domain (Dbl homologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity.

References

  1. "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. November 2005. doi:10.1242/jcs.02671. PMID 16254241. 
  2. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. December 2002. doi:10.1242/jcs.00219. PMID 12432077. 

Further reading